RT Journal Article
T1 Increased biomagnetic activity in healthy elderly with subjective memory complaints
A1 Maestu Unturbe, Fernando
A1 Baykova, Evgenia
A1 Ruiz Sánchez de León, José María
A1 Montejo, Pedro
A1 Montenegro Peña, María Mercedes
A1 Llanero Luque, Marcos
A1 Solesio, Elena
A1 Gil Gregorio, Pedro
A1 Yubero Pancorbo, Raquel
A1 Paul Lapedriza, Nuria Ascensión
A1 Pozo, Francisco del
A1 Nevado Pérez, Ángel
AB Objective. Subjective memory complaints (SMCs) are frequently reported by elderly people with or without objective cognitive impairment (OMI) as assessed by neuropsychological tests. We investigate whether SMCs are associated with altered brain biomagnetic patterns even in the absence of OMI. Methods. We report spatio-temporal patterns of brain magnetic activity recorded with magnetoencephalography during a memory task in 51 elderly participants divided into the following groups: patients with mild cognitive impairment (MCI) with SMC and OMI, individuals with SMC but not OMI, and healthy controls without neither SMC nor OMI. Exclusion criteria for all three groups included a diagnosis of depression or any other psychiatric condition. Results. No statistically significant differences were found between MCI patients and participants with SMC. However, the SMC showed higher activation, between 200 and 900 ms after stimulus onset, than the control group in posterior ventral regions and in the dorsal pathway. MCI patients showed higher activation than the control group in the posterior part of the ventral pathway. Conclusions. These findings suggest that similar physiological mechanisms may underlie SMC and MCI, which could be two stages in a cognitive continuum. Significance. MEG provide different neurophysiological profiles between SMC and control subjects.
PB Elsevier
SN 1388-2457
YR 2011
FD 2011-03
LK https://hdl.handle.net/20.500.14352/112441
UL https://hdl.handle.net/20.500.14352/112441
LA eng
NO Maestu-Unturbe, F., Baykova, E., Ruiz-Sánchez de León, J.M., Montejo-Carrasco, P., Montenegro-Peña, M., Llanero-Luque, M., Solesio-Jofre de Villegas, E., Gil, P., Yubero, R., Paul-Lapedriza, N., del Pozo, F. y Nevado, A. (2011). Increased biomagnetic activity in healthy elderly with subjective memory complaints. Clinical Neurophysiology, 122(3), 499–505.
NO Erratum in:Corrigendum to "Increased biomagnetic activity in healthy elderly with subjective memory complaints".Maestu F, Baykova E, Ruiz-Sánchez de León JM, Montejo P, Montenegro M, Llanero M, Solesio E, Gil P, Yubero R, Paul N, Pozo F, Nevado A.Published in Clinical Neurophysiology, 2022, 136, 250. doi: 10.1016/j.clinph.2022.02.002.
DS Docta Complutense
RD 24 dic 2025