RT Journal Article T1 Candidate gene analysis of osteochondrosis in Spanish Purebred horses A1 Sevane Fernández, Natalia A1 Dunner Boxberger, Helene Susana A1 Boado, A. A1 Cañón Ferreras, Francisco Javier AB Equine osteochondrosis (OC) is a frequent developmental orthopaedic disease with high economic impact on the equine industry and may lead to premature retirement of the animal as a result of chronic pain and lameness. The genetic background of OC includes different genes affecting several locations; however, these genetic associations have been tested in only one or few populations, lacking the validation in others. The aim of this study was to identify the genetic determinants of OC in the Spanish Purebred horse breed. For that purpose, we used a candidate gene approach to study the association between loci previously implicated in the onset and development of OC in other breeds and different OC locations using radiographic data from 144 individuals belonging to the Spanish Purebred horse breed. Of the 48 polymorphisms analysed, three single nucleotide polymorphisms (SNPs) located in the FAF1, FCN3 and COL1A2 genes were found to be associated with different locations of OC lesions. These data contribute insights into the complex gene networks underlying the multifactorial disease OC, and the associated SNPs could be used in a marker-assisted selection strategy to improve horse health, welfare and competitive lifespan. PB Wiley SN 0268-9146 YR 2016 FD 2016-07-16 LK https://hdl.handle.net/20.500.14352/103957 UL https://hdl.handle.net/20.500.14352/103957 LA eng NO Sevane N, Dunner S, Boado A, Cañon J (2016) Candidate gene analysis of osteochondrosis in Spanish Purebred horses. Animal Genetics 47, 570-578. DOI: 10.1111/age.12453 NO Ministerio de Ciencia, Innovación y Universidades DS Docta Complutense RD 22 abr 2025