RT Journal Article
T1 Induction of the calcineurin variant CnAβ1 after myocardial infarction reduces post-infarction ventricular remodelling by promoting infarct vascularization
A1 López-Olañeta, Marina M.
A1 Villalba Orero, María
A1 Gómez-Salinero, Jesús M.
A1 Jiménez-Borreguero, Luis J.
A1 Breckenridge, Ross
A1 Ortiz Sánchez, Paula
A1 García-Pavía, Pablo
A1 Ibáñez, Borja
A1 Lara-Pezzi, Enrique
AB Ventricular remodelling following myocardial infarction progressively leads to loss of contractile capacity and heart failure. Although calcineurin promotes maladaptive cardiac hypertrophy, we recently showed that the calcineurin splicing variant, CnAβ1, has beneficial effects on the infarcted heart. However, whether this variant limits necrosis or improves remodelling is still unknown, precluding translation to the clinical arena. Here, we explored the effects and therapeutic potential of CnAβ1 overexpression post-infarction.
PB European Society of Cardiology
SN 1755-3245
YR 2014
FD 2014
LK https://hdl.handle.net/20.500.14352/95565
UL https://hdl.handle.net/20.500.14352/95565
LA eng
NO Marina M. López-Olañeta, María Villalba, Jesús M. Gómez-Salinero, Luis J. Jiménez-Borreguero, Ross Breckenridge, Paula Ortiz-Sánchez, Pablo García-Pavía, Borja Ibáñez, Enrique Lara-Pezzi, Induction of the calcineurin variant CnAβ1 after myocardial infarction reduces post-infarction ventricular remodelling by promoting infarct vascularization, Cardiovascular Research, Volume 102, Issue 3, 1 June 2014, Pages 396–406, https://doi.org/10.1093/cvr/cvu068
NO European Commission
NO Ministerio de Ciencia e Innovación (España)
NO Comunidad de Madrid
NO Ministerio de Economía y Competitividad (España)
DS Docta Complutense
RD 9 abr 2025