RT Journal Article
T1 Membrane curvature induces cardiolipin sorting
A1 Beltrán De Heredia Rodríguez, Elena
A1 Tsai, Feng-Ching
A1 Salinas-Almaguer, Samuel
A1 Cao García, Francisco Javier
A1 Bassereau, Patricia
A1 Monroy, Francisco
AB Cardiolipin is a cone-shaped lipid predominantly localized in curved membrane sites of bacteria and in the mitochondrial cristae. This specific localization has been argued to be geometry-driven, since the CL’s conical shape relaxes curvature frustration. Although previous evidence suggests a coupling between CL concentration and membrane shape in vivo, no precise experimental data are available for curvature-based CL sorting in vitro. Here, we test this hypothesis in experiments that isolate the effects of membrane curvature in lipidbilayer nanotubes. CL sorting is observed with increasing tube curvature, reaching a maximum at optimal CL concentrations, a fact compatible with self-associative clustering. Observations are compatible with a model of membrane elasticity including van der Waals entropy, from which a negative intrinsic curvature of −1.1 nm−1 is predicted for CL. The results contribute to understanding the physicochemical interplay between membrane curvature and composition, providing key insights into mitochondrial and bacterial membrane organization and dynamics.
PB Nature Research
YR 2019
FD 2019-06-20
LK https://hdl.handle.net/20.500.14352/104514
UL https://hdl.handle.net/20.500.14352/104514
LA eng
NO Beltrán-Heredia, E., Tsai, FC., Salinas-Almaguer, S. et al. Membrane curvature induces cardiolipin sorting. Commun Biol 2, 225 (2019). https://doi.org/10.1038/s42003-019-0471-x
NO German Research Foundation
NO Ministerio de Economía y Competitividad (España)
NO European Commission
NO Comunidad de Madrid
NO European Molecular Biology Organization
NO European Union Marie Curie Actions
NO Fulbright Foundation
NO Ministerio de Educación, Cultura y Deportes (España)
DS Docta Complutense
RD 11 abr 2025