RT Journal Article
T1 Clinical and Molecular-Genetic Insights into the Role of Oxidative Stress in Diabetic Retinopathy: Antioxidant Strategies and Future Avenues
A1 Sanz González, Silvia María
A1 García Medina, José Javier
A1 Zanón Moreno, Vicente
A1 López Gálvez, María Isabel
A1 Galarreta Mira, David
A1 Duarte, Lilianne
A1 Valero Velló, Mar
A1 Ramírez Sebastián, Ana Isabel
A1 Arévalo, J. Fernando
A1 Pinazo Durán, María Dolores
AB Reactive oxygen species (ROS) overproduction and ROS-signaling pathways activation attack the eyes. We evaluated the oxidative stress (OS) and the effects of a daily, core nutritional supplement regimen containing antioxidants and omega 3 fatty acids (A/ω3) in type 2 diabetics (T2DM). A case-control study was carried out in 480 participants [287 T2DM patients with (+)/without (−) diabetic retinopathy (DR) and 193 healthy controls (CG)], randomly assigned to a daily pill of A/ω3. Periodic evaluation through 38 months allowed to outline patient characteristics, DR features, and classic/OS blood parameters. Statistics were performed by the SPSS 24.0 program. Diabetics displayed significantly higher circulating pro-oxidants (p = 0.001) and lower antioxidants (p = 0.0001) than the controls. Significantly higher plasma malondialdehyde/thiobarbituric acid reactive substances (MDA/TBARS; p = 0.006) and lower plasma total antioxidant capacity (TAC; p = 0.042) and vitamin C (0.020) was found in T2DM + DR versus T2DM-DR. The differential expression profile of solute carrier family 23 member 2 (SLC23A2) gene was seen in diabetics versus the CG (p = 0.001), and in T2DM + DR versus T2DM − DR (p < 0.05). The A/ω3 regime significantly reduced the pro-oxidants (p < 0.05) and augmented the antioxidants (p < 0.05). This follow-up study supports that a regular A/ω3 supplementation reduces the oxidative load and may serve as a dietary prophylaxis/adjunctive intervention for patients at risk of diabetic blindness.
PB MDPI
SN ESSN 2076-3921
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/7528
UL https://hdl.handle.net/20.500.14352/7528
LA eng
NO Received: 6 September 2020 / Revised: 29 October 2020 / Accepted: 3 November 2020 / Published: 9 November 2020This article belongs to the Special Issue Oxidative Stress in Human Diseases: Focus on Redox Status Assessment in Biological Fluids, Tissues and Cells
NO Ministerio de Ciencia e Innovación (MICINN)
NO Instituto de salud Carlos III (ISCIII)/FEDER
DS Docta Complutense
RD 11 may 2025