RT Journal Article
T1 The habenulo-interpeduncular and mammillothalamic tracts: early developed fiber tracts in the human fetal diencephalon
A1 Cho, Kwang Ho
A1 Mori, Shigemi
A1 Jang, Hyung Suk
A1 Kim, Ji Hyun
A1 Abe, Hiroshi
A1 Rodríguez Vázquez, José Francisco
A1 Murakami, Gen
AB Purpose: The habenulo-interpeduncular (HI) and mammillothalamic (MT) tracts are phylogenetically ancient. The clinical relevance of these tracts has recently received attention. In this work, we map the anatomy the developing HI and MT.Methods: To investigate the topographical anatomy of developing fiber tracts in and around the diencephalon, we examined the horizontal, frontal, and sagittal serial paraffin sections of 28 human fetuses at 8-12 weeks of gestation.Results: In all specimens, eosinophilic early fiber bundles were limited to the bilateral HI and MT tracts in contrast to pale-colored later developing fibers such as the thalamocortical projections and optic tract. The HI and MT tracts ran nearly parallel and sandwiched the thalamus from the dorsal and ventral sides, respectively. The nerve tract course appeared to range from 5-7 mm for the HI tract and 3-5 mm for the MT tract in 15 specimens at 11-12 weeks. The HI tract was embedded in, adjacent to, or distant from the developing parvocellular red nucleus.Conclusions: In early human fetuses, HI and MT tracts might be limited pathways for primitive cholinergic fiber connections between the ventral midbrain and epithalamic limbic system.
PB Springer Nature
SN 0256-7040
YR 2014
FD 2014-05-23
LK https://hdl.handle.net/20.500.14352/110181
UL https://hdl.handle.net/20.500.14352/110181
LA eng
NO Cho KH, Mori S, Jang HS, Kim JH, Abe H, Rodriguez-Vazquez JF, Murakami G. The habenulo-interpeduncular and mammillothalamic tracts: early developed fiber tracts in the human fetal diencephalon. Childs Nerv Syst. 2014 Sep;30(9):1477-84. doi: 10.1007/s00381-014-2432-5
NO Wonkwang University
DS Docta Complutense
RD 21 dic 2025