RT Journal Article
T1 Unlocking the in vitro neuroprotection of sloe residues phenolic extracts by bioanalytical and chemometric strategies
A1 Gómez Mejía, Esther
A1 Vicente Zurdo, David
A1 Rosales Conrado, Noelia
A1 León González, María Eugenia de
AB Wild fruits, particularly the underutilized sloe (Prunus spinosa), are gaining interest as natural antioxidants, with residues from liqueur production being a source of bioactive compounds. This study proposes a sustainable approach for valorizing sloe residues, seeds and skins, by employing an innovative green extraction method. HPLC-ESI-QTOF and spectrophotometric techniques were used to explore the phenolic profile, highlighting the predominance of quercetin, 2,3-dihydroxybenzoic and ferulic acids (9.7–57 μg·g−1). In addition, the presence of Cu, Zn and Ca was confirmed by atomic absorption spectroscopy. Simultaneously, their neuroprotective potential against Alzheimer's disease (AD) was studied by exploring the inhibition of beta-amyloid aggregation and oxidative stress cytoprotection in SH-SY5Y cell line, standing out 1 μg·g−1 and 10 μg·g−1 extracts of sloe skin. Phenolic composition was correlated with bioactivities by means of multivariate analysis. These results contributed to highlight the potential of this bio-residue as a neuroprotective agent against AD in pharmaceutical and nutraceutical industries.
PB Elsevier
YR 2024
FD 2024
LK https://hdl.handle.net/20.500.14352/109089
UL https://hdl.handle.net/20.500.14352/109089
LA eng
NO Universidad Complutense de Madrid
NO Comunidad de Madrid
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 6 abr 2025