RT Journal Article
T1 Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer
A1 Morán, Alberto
A1 García-Aranda, Carmen
A1 Díaz-López, Antonio
A1 Iniesta Serrano, María Pilar
A1 Juan Chocano, María Del Carmen De
A1 Sánchez Pernaute, Andrés
A1 Torres García, Antonio José
A1 Díaz-Rubio García, Eduardo
A1 Balibrea Cantero, José Luis
A1 Benito De Las Heras, Manuel R.
AB The main aim of this study was to evaluate the clinical relevance of Gelatinases in colorectal cancer (CRC). Ninety-five CRCs and their paired normal tissues were investigated to detect total levels of MMP-9, MMP-2, and the tissue inhibitors TIMP-1 and TIMP-2. Also, pro-MMP and MMP activity, and potential associations with clinical parameters were estimated. MMP-9, MMP-2 and TIMP-1 levels were greater in CRCs than in normal tissues, differences being significant for MMP-9 and TIMP-1. However, TIMP-2 showed significantly lower levels in tumour samples. Moreover, significant differences in the state of activation between gelatinases were found. TIMP-1 low levels were significantly associated with poor clinical outcome of patients. According to these data, different roles have to be attributed to MMP-2 and MMP-9 in CRC progression. Moreover, TIMP-1 level evaluation emerges as the main prognostic factor in relation to Gelatinases A and B activity in CRC.
PB SPANDIDOS PUBL LTD
SN 1021-335X
YR 2005
FD 2005
LK https://hdl.handle.net/20.500.14352/116227
UL https://hdl.handle.net/20.500.14352/116227
LA eng
NO Morán A, Iniesta P, García-Aranda C, De Juan C, Díaz-López A, Sánchez- Pernaute A, Torres AJ, Díaz-Rubio E, Balibrea JL, Benito M. Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer. Oncol Rep. 2005 Jan;13(1):115-20. PMID: 15583811.
DS Docta Complutense
RD 25 abr 2025