RT Journal Article
T1 Bicalutamide Enhances Conventional Chemotherapy in In Vitro and In Vivo Assays Using Human and Canine Inflammatory Mammary Cancer Cell Lines
A1 Crespo, Belén
A1 Illera Del Portal, Juan Carlos
A1 Silván Granado, Gema
A1 López Plaza, Paula
A1 Herrera de la Muela, María
A1 De la Puente Yagüe, Miriam
A1 Díaz Del Arco, Cristina
A1 Andrés Gamazo, Paloma Jimena de
A1 Illera, María José
A1 Cáceres Ramos, Sara Cristina
AB Human inflammatory breast cancer (IBC) and canine inflammatory mammary cancer (IMC) are highly aggressive neoplastic diseases that share numerous characteristics. In IBC and IMC, chemotherapy produces a limited pathological response and anti-androgen therapies have been of interest for breast cancer treatment. Therefore, the aim was to evaluate the effect of a therapy based on bicalutamide, a non-steroidal anti-androgen, with doxorubicin and docetaxel chemotherapy on cell proliferation, migration, tumor growth, and steroid-hormone secretion. An IMC-TN cell line, IPC-366, and an IBC-TN cell line, SUM149, were used. In vitro assays revealed that SUM149 exhibited greater sensitivity, reducing cell viability and migration with all tested drugs. In contrast, IPC-366 exhibited only significant in vitro reductions with docetaxel as a single agent or in different combinations. Decreased estrogen levels reduced in vitro tumor growth in both IMC and IBC. Curiously, doxorubicin resulted in low efficacy, especially in IMC. In addition, all drugs reduced the tumor volume in IBC and IMC by increasing intratumoral testosterone (T) levels, which have been related with reduced tumor progression. In conclusion, the addition of bicalutamide to doxorubicin and docetaxel combinations may represent a potential treatment for IMC and IBC.
PB MDPI
YR 2024
FD 2024-07-19
LK https://hdl.handle.net/20.500.14352/107694
UL https://hdl.handle.net/20.500.14352/107694
LA eng
NO Crespo, B.; Illera, J.C.; Silvan, G.; Lopez-Plaza, P.; Herrera de la Muela, M.; de la Puente Yague, M.; Diaz del Arco, C.; de Andrés, P.J.; Illera, M.J.; Caceres, S. Bicalutamide Enhances Conventional Chemotherapy in In Vitro and In Vivo Assays Using Human and Canine Inflammatory Mammary Cancer Cell Lines. Int. J. Mol. Sci. 2024, 25, 7923. https://doi.org/10.3390/ ijms25147923
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 10 abr 2025