%0 Journal Article
%A Jiménez, José Luis
%A Gómez, Rafael
%A Briz, Veronica
%A Madrid González, Ricardo
%A Bryszewsk, Maria
%A Mata, Francisco .Javier. de la
%A Muñoz-Fernández, María Ángeles 
%T Carbosilane dendrimers as carriers of siRNA
%D 2012
%@ 1773-2247
%U https://hdl.handle.net/20.500.14352/99626
%X Despite the enormous possibilities of RNAi, there still exist many problems that need to be addressed. Obstacles in delivery, target cell transfection, stability/degradation, transient activity, secondary effects, toxicity caused by the delivery vector, and resistance all hinder the path of carrying out in vivo experiments with RNAi and further developing RNAi as a new therapy for clinical use. Notwithstanding, the majority of research that uses RNAi depends on a delivery vector of some kind. This review offers a brief overview of the current status of carbosilane dendrimers as siRNA delivery vectors.
%~