RT Journal Article
T1 The role of Hsp70 in oxi-inflamm-aging and its use as a potential biomarker of lifespan
A1 Martínez de Toda Cabeza, Irene
A1 Fuente del Rey, Mónica de la
AB The heat-shock protein 70 (HSPA1A or Hsp70) acts as a cellular defense mechanism its expression being induced under stressful conditions. Aging has been related to an impairment in this induction. However, an extended longevity has been associated with its increased expression. According to the oxidation-inflammation theory of aging, chronic oxidative stress and inflammatory stress situations (with higher levels of oxidant and inflammatory compounds and lower antioxidant and anti-inflammatory defenses) are the basis of the age-related alterations of body cells. Since oxidation and inflammation are interlinked processes, and Hsp70 has been shown to confer protection against the harmful effects of oxidative stress as well as modulating the inflammatory status, it could play a role as a regulator of the rate of aging. This role may be different in mitotic and post-mitotic tissues due to the differences in their agerelated mechanisms of response, such as apoptosis. Mechanisms affected by Hsp70 that can interfere with the deleterious effects of excessive oxidative stress and chronic low-grade inflammation and that are closely related to the aging process have been detailed. In addition, the potential use of the basal levels (with their differences in post-mitotic and mitotic tissues), the inducible levels, as well as the extracellular levels of Hsp70 as possible biomarkers of the rate of aging and lifespan, have also been discussed.
PB Springer
SN 1389-5729, ESSN: 1573-6768
YR 2015
FD 2015-12
LK https://hdl.handle.net/20.500.14352/23298
UL https://hdl.handle.net/20.500.14352/23298
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Instituto de Salud Carlos III (ISCIII)/FEDER
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 14 abr 2025