RT Journal Article
T1 Gut microbiota, innate immune pathways, and inflammatory control mechanisms in patients with major depressive disorder
A1 González Pinto, Ana
A1 García, Saínza
A1 Diego Adeliño, Javier De
A1 Carceller Sindreu, Mar
A1 Sarramea, Fernando
A1 Caballero Villarraso, Javier
A1 Gracia García, Patricia
A1 De la Cámara, Concepción
A1 Rodríguez, Juan M.
A1 Caso Fernández, Javier Rubén
A1 Mac-Dowell Mata, Karina Soledad
A1 Leza Cerro, Juan Carlos
A1 Gómez-Lus Centelles, María Luisa
A1 Agüera Ortiz, Luis Fernando
A1 Alba Rubio, Claudio
AB Although alterations in the gut microbiota have been linked to the pathophysiology of major depressive disorder (MDD), including through effects on the immune response, our understanding is deficient about the straight connection patterns among microbiota and MDD in patients. Male and female MDD patients were recruited: 46 patients with a current active MDD (a-MDD) and 22 in remission or with only mild symptoms (r-MDD). Forty-five healthy controls (HC) were also recruited. Psychopathological states were assessed, and fecal and blood samples were collected. Results indicated that the inducible nitric oxide synthase expression was higher in MDD patients compared with HC and the oxidative stress levels were greater in the a-MDD group. Furthermore, the lipopolysaccharide (an indirect marker of bacterial translocation) was higher in a-MDD patients compared with the other groups. Fecal samples did not cluster according to the presence or the absence of MDD. There were bacterial genera whose relative abundance was altered in MDD:<jats:italic>Bilophila</jats:italic>(2-fold) and<jats:italic>Alistipes</jats:italic>(1.5-fold) were higher, while<jats:italic>Anaerostipes</jats:italic>(1.5-fold) and<jats:italic>Dialister</jats:italic>(15-fold) were lower in MDD patients compared with HC. Patients with a-MDD presented higher relative abundance of<jats:italic>Alistipes</jats:italic>and<jats:italic>Anaerostipes</jats:italic>(1.5-fold) and a complete depletion of<jats:italic>Dialister</jats:italic>compared with HC. Patients with r-MDD presented higher abundance of<jats:italic>Bilophila</jats:italic>(2.5-fold) compared with HC. Thus, the abundance of bacterial genera and some immune pathways, both with potential implications in the pathophysiology of depression, appear to be altered in MDD, with the most noticeable changes occurring in patients with the worse clinical condition, the a-MDD group.
PB Springer Nature
SN 2158-3188
YR 2021
FD 2021-12-21
LK https://hdl.handle.net/20.500.14352/96768
UL https://hdl.handle.net/20.500.14352/96768
LA eng
NO Caso JR, MacDowell KS, González-Pinto A, García S, de Diego-Adeliño J, Carceller-Sindreu M, Sarramea F, Caballero-Villarraso J, Gracia-García P, De la Cámara C, Agüera L, Gómez-Lus ML, Alba C, Rodríguez JM, Leza JC. Gut microbiota, innate immune pathways, and inflammatory control mechanisms in patients with major depressive disorder. Transl Psychiatry. 2021 Dec 21;11(1):645. doi: 10.1038/s41398-021-01755-3. PMID: 34934041.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Centro de Investigación Biomédica en Red de Salud Mental
NO Catalan Intensification Programme
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 16 abr 2025