RT Journal Article
T1 Ionotropic Gelation-Based Synthesis of Chitosan-Metal Hybrid Nanoparticles Showing Combined Antimicrobial and Tissue Regenerative Activities
A1 Lozano Chamizo, Laura
A1 Luengo Morato, Yurena
A1 Ovejero Paredes, Karina
A1 Contreras Cáceres, Rafael
A1 Marciello, Marzia
A1 Filice, Marco
AB The treatment of skin wounds poses significant clinical challenges, including the risk of bacterial infection. In particular due to its antimicrobial and tissue regeneration abilities chitosan (a polymeric biomaterial obtained by the deacetylation of chitin) has received extensive attention for its effectiveness in promoting skin wound repair. On the other hand, due to their intrinsic characteristics, metal nanoparticles (e.g., silver (Ag), gold (Au) or iron oxide (Fe3O4)) have demonstrated therapeutic properties potentially useful in the field of skin care. Therefore, the combination of these two promising materials (chitosan plus metal oxide NPs) could permit the achievement of a promising nanohybrid with enhanced properties that could be applied in advanced skin treatment. In this work, we have optimized the synthesis protocol of chitosan/metal hybrid nanoparticles by means of a straightforward synthetic method, ionotropic gelation, which presents a wide set of advantages. The synthesized hybrid NPs have undergone to a full physicochemical characterization. After that, the in vitro antibacterial and tissue regenerative activities of the achieved hybrids have been assessed in comparison to their individual constituent. As result, we have demonstrated the synergistic antibacterial plus the tissue regeneration enhancement of these nanohybrids as a consequence of the fusion between chitosan and metallic nanoparticles, especially in the case of chitosan/Fe3O4 hybrid nanoparticles.
SN 2073-4360
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/100710
UL https://hdl.handle.net/20.500.14352/100710
LA eng
NO Lozano Chamizo, Laura, et al. «Ionotropic Gelation-Based Synthesis of Chitosan-Metal Hybrid Nanoparticles Showing Combined Antimicrobial and Tissue Regenerative Activities». Polymers, vol. 13, n.o 22, noviembre de 2021, p. 3910.  https://doi.org/10.3390/polym13223910.
NO Comunidad de Madrid
NO Federación Española de Enfermedades Raras
NO Universidad Complutense de Madrid
NO Instituto de Salud Carlos III
NO Centro Nacional de Investigaciones Cardiovasculares
NO Ministerio de Economía, Comercio y Empresa (España)
DS Docta Complutense
RD 19 jun 2026