RT Journal Article
T1 Kupffer cells and alcoholic liver disease
A1 Cubero Palero, Francisco Javier
A1 Nieto, Natalia
AB Liver disease is a major cause of illness and death worldwide. A central component in the complex network leading to the development of alcoholic liver disease is the activation of Kupffer cells by endotoxin and other soluble mediators. Alcohol consumption induces a state of "leaky gut increasing plasma and liver endotoxin levels. When Kupffer cells become activated, they interact with a complex of proteins located on the extracellular membrane signaling to produce a wide array of soluble factors, including cytokines, chemokines, growth factors, cyclooxygenase and lipoxygenase metabolites, and reactive oxygen species such as superoxide anion, hydrogen peroxide, and nitric oxide, all of which provide physiologically diverse and pivotal paracrine effects on all other liver cell types and, ultimately, liver injury. Kupffer cells are also central to the liver homeostatic response to injury as upon cellular degenerative changes, they immediately respond to the insult and release mediators to orchestrate inflammatory and reparative responses. Thus, the homeostatic responses are initiated by Kupffer cell-derived mediators at the cellular level and underlie the liver s defense and reparative mechanisms against injury. In order to understand better the role of Kupffer cells in the onset of liver injury, animal models in which Kupffer cells are inactivated, and cell culture settings (e.g. co-cultures) are being used with promising results that advance our understanding of alcoholic liver disease.
PB Arán Ediciones
SN 1130-0108
YR 2006
FD 2006-05-23
LK https://hdl.handle.net/20.500.14352/98299
UL https://hdl.handle.net/20.500.14352/98299
LA eng
NO Cubero FJ, Nieto N. Kupffer cells and alcoholic liver disease. Rev Esp Enferm Dig. 2006 Jun;98(6):460-72. English, Spanish. doi: 10.4321/s1130-01082006000600007. PMID: 16948545.
NO Department of Medicine. Division of Liver Diseases. Mount Sinai School of Medicine. New York, USA
NO National Institute of Diabetes and Digestive and Kidney Diseases (US Public Health Service)
DS Docta Complutense
RD 10 abr 2025