RT Journal Article
T1 The preventive and therapeutic consumption of meat enriched with carob fruit extract, rich in phenolic compounds, improves colonic antioxidant status in late-stage T2DM rats
A1 Macho González, Adrián
A1 Apaza Ticona, Luis Nestor
A1 Redondo Castillejo, Rocío
A1 Hernández Martín, Marina
A1 Sánchez Muniz, Francisco José
A1 Hernáiz, María José
A1 Bastida Codina, Sara
A1 Benedí González, Juana María
A1 Bocanegra De Juana, Aranzazu
A1 López-Oliva Muñoz, María Elvira
A1 Mateos Vega, Carmen
A1 Garcimartín Álvarez, Alba
AB Oxidative stress is prevalent in Type 2 Diabetes Mellitus (T2DM) and has been associated with high meat consumption. Carob Fruit Extract (CFE) contains phenolic compounds, making it a suitable functional ingredient. Current study aims to evaluate the effect of CFE-enriched meat (CFE-meat) consumption on the antioxidant status of proximal and distal colon, and its relationship with fecal phenolic compounds in late-stage T2DM rats. Three groups of eight rats were studied: 1) D, fed control-meat; 2) ED, fed CFE-meat since the beginning of the study; 3) DE, fed CFE-meat after confirming T2DM. CFE-meat consumption reduces colonic oxidative stress mainly in the proximal section and helps to ameliorate glutathione metabolism and antioxidant score. Difference between ED and DE groups were associated with colon homeostasis and T2DM progression suggesting greater fermentation but lower absorption in the DE group. CFE appears as a promising tool to improve the antioxidant status observed in late-stage T2DM.
PB Elsevier
SN 0308-8146
YR 2024
FD 2024-08-30
LK https://hdl.handle.net/20.500.14352/110793
UL https://hdl.handle.net/20.500.14352/110793
LA eng
NO Macho-González A, Apaza Ticona L, Redondo-Castillejo R, Hernández-Martín M, Sánchez-Muniz FJ, Hernáiz MJ, Bastida S, Benedí J, Bocanegra A, López-Oliva ME, Mateos-Vega C, Garcimartín A. The preventive and therapeutic consumption of meat enriched with carob fruit extract, rich in phenolic compounds, improves colonic antioxidant status in late-stage T2DM rats. Food Chem. 2024 Aug 30;450:139339. doi: 10.1016/j.foodchem.2024.139339
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 20 abr 2025