RT Journal Article
T1 Bioaccesibility, Metabolism, and Excretion of Lipids Composing Spent Coffee Grounds
A1 Iriondo De Hond, Amaia
A1 Cornejo, Fresia Santillan
A1 Fernandez-Gomez, Beatriz
A1 Vera, Gema
A1 Guisantes-Batan, Eduardo
A1 Alonso, Sergio Gomez
A1 San Andrés Larrea, Manuel Ignacio
A1 Sánchez-Fortún Rodríguez, Sebastián
A1 Lopez-Gomez, Laura
A1 Uranga, Jose Antonio
A1 Abalo, Raquel
A1 del Castillo, Maria Dolores
AB The bioaccessibility, metabolism, and excretion of lipids composing spent coffee grounds (SCGs) were investigated. An analysis of mycotoxins and an acute toxicity study in rats were performed for safety evaluation. Total fat, fatty acids, and diterpenes (cafestol and kahweol) were determined in SCGs and their digests obtained in vitro. A pilot repeated intake study was carried out in Wistar rats using a dose of 1 g SCGs/kg b.w. for 28 days. Fat metabolism was evaluated by analysis of total fat, cholesterol, and histology in liver. The dietary fiber effect of SCGs was measured radiographically. The absence of mycotoxins and toxicity was reported in SCGs. A total of 77% of unsaturated fatty acids and low amounts of kahweol (7.09 µg/g) and cafestol (414.39 µg/g) were bioaccessible after in vitro digestion. A significantly lower (p < 0.1) accumulation of lipids in the liver and a higher excretion of these in feces was found in rats treated with SCGs for 28 days. No lipid droplets or liver damage were observed by histology. SCGs acutely accelerated intestinal motility in rats. SCGs might be considered a sustainable, safe, and healthy food ingredient with potential for preventing hepatic steatosis due to their effect as dietary fiber with a high fat-holding capacity.
PB MDPI
SN 2072-6643
YR 2019
FD 2019-06-23
LK https://hdl.handle.net/20.500.14352/12532
UL https://hdl.handle.net/20.500.14352/12532
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
DS Docta Complutense
RD 7 may 2024