RT Journal Article
T1 The value of metabolic parameters and textural analysis in predicting prognosis in locally advanced cervical cancer treated with chemoradiotherapy
A1 Pedraza, Sara
A1 Seiffert, Alexander P.
A1 Sarandeses Fernández, María Del Pilar
A1 Muñoz Lopez, Beatriz
A1 Gómez, Enrique J.
A1 Sánchez González, Patricia
A1 Pérez-Regadera Gómez, José Fermín
AB ObjectiveThe aim of the study was to assess the impact of clinical and metabolic parameters derived from 18F-FDG PET/CT (positron emission tomography–computed tomography) in patients with locally advanced cervical cancer (LACC) on prognosis.MethodsPatients with LACC of stage IB2-IVA treated by primary radiochemotherapy followed by brachytherapy were enrolled in this retrospective study. Indexes derived from standardized uptake value (SUV), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and textural features of the primary tumor were measured for each patient. Overall survival (OS) and recurrence-free survival (RFS) rates were calculated according to Kaplan–Meier and survival curves were compared using the log-rank test. Uni- and multivariate analyses were performed using the Cox regression model.ResultsA total of 116 patients were included. Median follow-up was 58 months (range: 1–129). A total of 36 (31%) patients died. Five-year OS and RFS rates were 69 and 60%, respectively. Univariate analyses indicated that FIGO stage, the presence of hydronephrosis, high CYFRA 21.1 levels, and textural features had a significant impact on OS and RFS. MTV as well as SCC-Ag concentration were also significantly associated with OS. On multivariate analysis, the presence of hydronephrosis, CYFRA 21.1, and sphericity were independent prognostics factors for OS and RFS. Also, SCC-Ag level, MTV, and GLZLM (gray-level zone length matrix) ZLNU (zone length non-uniformity) were significantly associated with OS.ConclusionClassical prognostic factors and tumor heterogeneity on pretreatment PET/CT were significantly associated with prognosis in patients with LACC.
PB Springer Nature
SN 0179-7158
YR 2022
FD 2022-01-24
LK https://hdl.handle.net/20.500.14352/71573
UL https://hdl.handle.net/20.500.14352/71573
LA eng
NO Pedraza, S., Seiffert, A. P., Sarandeses Fernández, M. P. et al. «The Value of Metabolic Parameters and Textural Analysis in Predicting Prognosis in Locally Advanced Cervical Cancer Treated with Chemoradiotherapy». Strahlentherapie Und Onkologie, vol. 198, n.o 9, septiembre de 2022, pp. 792-801. Crossref, https://doi.org/10.1007/s00066-022-01900-x.
NO CRUE-CSIC (Acuerdos Transformativos 2022)
DS Docta Complutense
RD 19 abr 2025