TY  - JOUR
AU  - Pérez Luz, Sara
AU  - Abdulrazzak, Hassan
AU  - Grillot-Courvalin, Catherine
AU  - Huxley, Clare
PY  - 2007
DO  - 10.1016/j.ygeno.2007.07.005
SN  - 0888-7543
UR  - https://hdl.handle.net/20.500.14352/93001
AB  - Hemophilia A is caused by mutations in the gene encoding factor VIII (F8) and is an important target for gene therapy. The F8 gene contains 26 exons spread over ∼186 kb and no work using the intact genomic locus has been carried out. We have...
LA  - eng
M2  - 610
KW  - Hemophilia A
KW  - Factor VIII
KW  - F8
KW  - Gene therapy
KW  - Bacterial artificial chromosome
KW  - BAC
KW  - Bacterial delivery
KW  - OriP/EBNA-1
KW  - Alphoid DNA
TI  - Factor VIII mRNA expression from a BAC carrying the intact locus made by homologous recombination
TY  - journal article
VL  - 90
ER  -