RT Journal Article T1 Considering the Effects and Maternofoetal Implications of Vascular Disorders and the Umbilical Cord A1 Sanchez Trujillo, Lara A1 García Montero, Cielo A1 Fraile Martínez, Oscar A1 Guijarro, Luis G. A1 Bravo Arribas, Coral A1 León Luis, Juan Antonio A1 Saez, Jose V. A1 Bujan, Julia A1 Álvarez Mon, Melchor A1 García Honduvilla, Natalio A1 Saez, Miguel A. A1 Ortega, Miguel A. AB The umbilical cord is a critical anatomical structure connecting the placenta with the foetus, fulfilling multiple functions during pregnancy and hence influencing foetal development, programming and survival. Histologically, the umbilical cord is composed of three blood vessels: two arteries and one vein, integrated in a mucous connective tissue (Wharton’s jelly) upholstered by a layer of amniotic coating. Vascular alterations in the umbilical cord or damage in this tissue because of other vascular disorders during pregnancy are worryingly related with detrimental maternofoetal consequences. In the present work, we will describe the main vascular alterations presented in the umbilical cord, both in the arteries (Single umbilical artery, hypoplastic umbilical artery or aneurysms in umbilical arteries) and the vein (Vascular thrombosis, aneurysms or varicose veins in the umbilical vein), together with other possible complications (Velamentous insertion, vasa praevia, hypercoiled or hypocoiled cord, angiomyxoma and haematomas). Likewise, the effect of the main obstetric vascular disorders like hypertensive disorders of pregnancy (specially pre-eclampsia) and chronic venous disease on the umbilical cord will also be summarized herein. PB MDPI SN 1648-9144 YR 2022 FD 2022-11-29 LK https://hdl.handle.net/20.500.14352/72320 UL https://hdl.handle.net/20.500.14352/72320 LA eng NO Unión Europea NO Comunidad de Madrid NO Instituto de Salud Carlos III NO Halekulani S.L DS Docta Complutense RD 10 abr 2025