RT Journal Article
T1 The Spanish biology/disease initiative within the human proteome project: Application to rheumatic diseases
A1 Ruiz Romero, Cristina
A1 Calamia, Valentina
A1 Albar, Juan P.
A1 Casal, J. Ignacio
A1 Corrales, F. J.
A1 Fernández Puente, Patricia
A1 Gil, Concha
A1 Mateos, Jesús
A1 Vivanco, Fernando
A1 Blanco, F.
AB The Spanish Chromosome 16 consortium is integrated in the global initiative Human Proteome Project, which aims to develop an entire map of the proteins encoded following a gene-centric strategy (C-HPP) in order to make progress in the understanding of human biology in health and disease (B/D-HPP). Chromosome 16 contains many genes encoding proteins involved in the development of a broad range of diseases, which have a significant impact on the health care system. The Spanish HPP consortium has developed a B/D platform with five programs focused on selected medical areas: cancer, obesity, cardiovascular, infectious and rheumatic diseases. Each of these areas has a clinical leader associated to a proteomic investigator with the responsibility to get a comprehensive understanding of the proteins encoded by Chromosome 16 genes. Proteomics strategies have enabled great advances in the area of rheumatic diseases, particularly in osteoarthritis, with studies performed on joint cells, tissues and fluids. BIOLOGICAL SIGNIFICANCE:In this manuscript we describe how the Spanish HPP-16 consortium has developed a B/D platform with five programs focused on selected medical areas: cancer, obesity, cardiovascular, infectious and rheumatic diseases. Each of these areas has a clinical leader associated to a proteomic investigator with the responsibility to get a comprehensive understanding of the proteins encoded by Chromosome 16 genes. We show how the Proteomic strategy has enabled great advances in the area of rheumatic diseases, particularly in osteoarthritis, with studies performed on joint cells, tissues and fluids. This article is part of a Special Issue entitled: HUPO 2014.
PB Elsevier
SN 1874-3919
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/34905
UL https://hdl.handle.net/20.500.14352/34905
LA eng
NO Fondo Investigación Sanitaria-Spain
NO Secretaría I + D + I Xunta de Galicia
DS Docta Complutense
RD 29 abr 2025