RT Journal Article
T1 Impacts of age and sex on retinal layer thicknesses measured by spectral domain optical coherence tomography with Spectralis
A1 Nieves Moreno, María
A1 Martínez de la Casa, Jose Maria
A1 Morales Fernández, Laura
A1 Sánchez Jean, Rubén
A1 Sáenz Francés, Federico
A1 García Feijoo, Julián
AB Objective: To examine differences in individual retinal layer thicknesses measured by spectral domain optical coherence tomography (SD-OCT) (Spectralis®) produced with age and according to sex.Design: Cross-sectional, observational study.Methods: The study was conducted in 297 eyes of 297 healthy subjects aged 18 to 87 years. In one randomly selected eye of each participant the volume and mean thicknesses of the different macular layers were measured by SD-OCT using the instrument's macular segmentation software.Main outcome measures: Volume and mean thickness of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigmentary epithelium (RPE) and photoreceptor layer (PR).Results: Retinal thickness was reduced by 0.24 μm for every one year of age. Age adjusted linear regression analysis revealed mean GCL, IPL, ONL and PR thickness reductions and a mean OPL thickness increase with age. Women had significantly lower mean GCL, IPL, INL, ONL and PR thicknesses and volumes and a significantly greater mRNFL volume than men.Conclusion: The thickness of most retinal layers varies both with age and according to sex. Longitudinal studies are needed to determine the rate of layer thinning produced with age.
PB Public Library Science
SN 1932-6203
YR 2018
FD 2018-03-09
LK https://hdl.handle.net/20.500.14352/12017
UL https://hdl.handle.net/20.500.14352/12017
LA eng
NO Received: December 7, 2017; Accepted: February 26, 2018; Published: March 9, 2018
DS Docta Complutense
RD 2 may 2024