RT Journal Article
T1 Mycobacterium tuberculosis complex in domestic goats in Southern Spain
A1 Jiménez-Martín, Débora
A1 García-Bocanegra, Ignacio
A1 Risalde, María A.
A1 Napp, Sebastian
A1 Domínguez, Mercedes
A1 Romero Martínez, Beatriz
A1 Moreno, Inmaculada
A1 Martínez, Remigio
A1 Cano-Terriza, David
AB Tuberculosis (TB) is a zoonotic infectious disease caused by bacteria belonging to the Mycobacterium tuberculosis complex (MTC), which can affect a wide variety of domestic and wild animal species. Although the role of goats as a reservoir of MTC bacteria has been evidenced, information about the circulation of MTC strains in this species is still very scarce. The aim of the present study was to determine the seroprevalence, spatial distribution, risk factors and MTC spoligotypes circulating in goats from Andalusia (Southern Spain), the Spanish region with the largest goat census and a hotspot area of TB in both cattle and wild ungulates. A total of 2155 serum samples from 80 goat flocks were analyzed by an in-house ELISA using the P22 protein complex as a coating antigen. Antibodies against MTC were detected in 473 goats (21.9%, 95% CI: 20.2–23.7) and the true seroprevalence was 22.3% (95% CI: 20.6–24.1). Seropositivity was found in 72 (90.0%) of the 80 flocks analyzed. The generalized estimating equation model showed that the management system (higher seroprevalence on intensive and semi-intensive farms), and the presence of hospital pens inside the regular stables, were risk factors potentially associated with MTC exposure in goats in Southern Spain. The spatial analysis identified a significant spatial cluster (p < 0.001) in Eastern Andalusia. A total of 16 different MTC spoligotypes, including five of M. caprae and eleven of M. bovis, were identified in goats between 2015 and 2022 in the study area, with SB0157 as the most frequently isolated. The results obtained indicate widespread and non-homogeneous spatial distribution of MTC in goat herds from Southern Spain. The high individual and herd-level seroprevalence values found suggest that goats could play a significant role in the maintenance and transmission of MTC in the study area. Our results highlight the importance of implementing control measures in this species.
PB Elsevier
SN 0167-5877
YR 2024
FD 2024-04-09
LK https://hdl.handle.net/20.500.14352/103147
UL https://hdl.handle.net/20.500.14352/103147
LA eng
NO Jimenez-Martin D, Garcia-Bocanegra I*, Risalde MA, Napp S, Dominguez M, Romero B, Moreno I, Martinez R and Cano-Terriza D. Mycobacterium tuberculosis complex in domestic goats in Southern Spain. Preventive Veterinary Medicine, 227:106204. 2024. (A). ISSN: 0167-5877. Impact factor 2022: 2.600. Category: Veterinary Sciences, Quartile: 1, Position: 21 of 143. DOI: 10.1016/j.prevetmed.2024.106204
NO Ministerio de Economía y Competitividad
NO Universidad de Córdoba
NO Insatituto de Salud Carlos III
NO Ministerio de Ciencia, Innovación y Universidades
DS Docta Complutense
RD 5 ago 2024