RT Journal Article
T1 Gene-environment interaction as a predictor of early adjustment in first episode psychosis
A1 Fraguas Herráez, David
A1 Díaz Caneja, Covadonga M.
A1 Corripio, Iluminada
A1 González Pinto, Ana
A1 Lobo, Antonio
A1 Bioque, Miguel
A1 Cuesta, Manuel J.
A1 Sanjuán, Julio
A1 Rodríguez Toscano, Elisa
A1 Arias, Bárbara
A1 Sarró, Salvador
A1 Cabrera, Bibiana
A1 Bulbena, Antoni
A1 Vieta, Eduard
A1 Castro Fornieles, Josefina
A1 Arango López, Celso
A1 Bernardo, Miguel
A1 Parellada Redondo, María José
AB Background: This study aims to explore the gene-environment interaction hypothesis applied to pre-symptomatic neurodevelopmental phenotypes of first episode psychosis (FEP), that is, genetic factors might increase vulnerability to the effects of environmental adverse conditions occurring at later stages of development.Methods:We constructed a schematic ‘two-hit’ model, with Val/Val homozygosity for the catechol-O-methyltransferase (COMT) Val158Met polymorphism as the ‘first hit’ and history of obstetric complications and parental socioeconomic status as ‘second hits’. Early adjustment,measured using the Premorbid Adjustment Scale,was considered the main outcome. The study population comprised 221 adolescents and adults with FEP and 191 sex- and agematched controls.Results: The interaction between the Val/Val COMT genotype and a positive history of obstetric complications plus lowparental socioeconomic status was significantly associated with poorer early adjustment. These results were observed both in FEP individuals and in controls, and remained significant after controlling for age, sex, and diagnosis.Conclusions: Individuals carrying Val/Val seem to bemore sensitive to the synergistic effect of environmental factors acting early in neurodevelopment, which leads to vulnerability phenotypes such as impaired early adjustment.
PB Elsevier
SN 0920-9964
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/114226
UL https://hdl.handle.net/20.500.14352/114226
LA eng
NO Fraguas, D., Díaz-Caneja, C. M., Corripio, I., González-Pinto, A., Lobo, A., Bioque, M., Cuesta, M. J., Sanjuán, J., Rodríguez-Toscano, E., Arias, B., Sarró, S., Cabrera, B., Bulbena, A., Vieta, E., Castro-Fornieles, J., Arango, C., Bernardo, M., & Parellada, M. (2017). Gene-environment interaction as a predictor of early adjustment in first episode psychosis. Schizophrenia Research, 189, 196-203. https://doi.org/10.1016/j.schres.2017.02.021
DS Docta Complutense
RD 17 abr 2025