RT Journal Article
T1 Improving Quality of Life Through Supervised Exercise in Oncology: A Systematic Review and Meta-Analysis of Randomized Trials in Breast and Prostate Cancer
A1 Cano Uceda, Arturo
A1 De Sousa De Sousa, Luis
A1 Bueno Fermoso, Rebeca
A1 Rozalén Bustín, Manuel
A1 Lucio Allende, Carmen
A1 Barba Ruiz, Manuel
A1 Sánchez Barroso, Lara
A1 Maté Muñoz, José Luis
A1 García Fernández, Pablo
AB Background: Cancer treatments often reduce quality of life (QoL), and non-pharmacological  options are limited. Supervised exercise shows promise, but its effectiveness across exercise  types and patient subgroups is unclear. Objective: This study aimed to assess the impact of supervised exercise on QoL in breast and prostate cancer patients, considering exercise type,  duration, and patient characteristics. Methods: A systematic review and meta-analysis including 26 randomized controlled trials (RCTs) and approximately 3500 participants was conducted according to PRISMA guidelines. PubMed, Web of Science, PEDro, SciELO, Cochrane, and Scopus were searched for randomized controlled trials (RCTs) published  between 2014 and 2024. Eligible studies involved adults with breast or prostate cancer undergoing supervised exercise versus usual care or unsupervised activity. Risk of bias was assessed with the Cochrane RoB 2.0 tool, methodological quality with the PEDro scale, and certainty of evidence using the GRADE approach. Results: Supervised exercisewas associated with significant improvements in QoL (SMD = 0.46; 95% CI: 0.22–0.70; p < 0.001), with considerable heterogeneity (I2 = 91.5%). Combined programs had the greatesteffect (SMD = 0.77), followed by high-intensity interval training (HIIT) (SMD = 0.30). Shorter interventions (≤12 weeks) yielded larger improvements. Effects were more consistentin women with breast cancer. Overall, the certainty of the evidence was low. Conclusions: Supervised therapeutic exercise is associated with significant improvements in QoL in breast and prostate cancer patients. Combined and well-structured programs, particularly of short duration, appear especially beneficial. These findings support the    integration of supervised exercise into standard oncological care. Further research should explore long-term sustainability and optimize interventions for specific patient profiles.
PB MDPI
SN 2411-5142
YR 2025
FD 2025-11-20
LK https://hdl.handle.net/20.500.14352/126417
UL https://hdl.handle.net/20.500.14352/126417
LA eng
NO Cano-Uceda, A.; De Sousa-De Sousa, L.; Bueno-Fermoso, R.; Rozalén-Bustín, M.; Lucio-Allende, C.; Barba-Ruiz, M.; Sánchez-Barroso, L.; Maté-Muñoz, J.L.; García-Fernández, P. Improving Quality of Life Through Supervised Exercise in Oncology: A Systematic Review and Meta-Analysis of Randomized Trials in Breast and Prostate Cancer. J. Funct. Morphol. Kinesiol. 2025, 10, 453.
DS Docta Complutense
RD 30 dic 2025