RT Journal Article
T1 Phenolic Acids and Flavonoids in Acetonic Extract from Quince (Cydonia oblonga Mill.): Nutraceuticals with Antioxidant and Anti-Inflammatory Potential
A1 Herrera Rocha, Karen Marlenne
A1 Rocha Guzmán, Nuria Elizabeth
A1 Gallegos Infante, José Alberto
A1 González Laredo, Rubén Francisco
A1 Larrosa Pérez, María Del Mar
A1 Moreno Jiménez, Martha Rocío
AB Quince (Cydonia oblonga Mill.) is a potential source of polyphenolic compounds related with beneficial biological processes. In this study polyphenols from quince fruit were extracted with aqueous acetone at different ratios. A polyphenol profile was identified and quantified by LC-ESI-QqQ. The antioxidant capacity (ORAC and DPPH) and anti-inflammatory effect (inhibition of COX-2 cyclooxygenase) were evaluated in vitro. The results indicated an effect of the aqueous acetone ratio on the extraction of polyphenolic compounds. The higher extraction yields of polyphenolic compounds were attained with 60–75% aqueous acetone. However, extracts obtained with 85% aqueous acetone promoted higher antioxidant and anti-inflammatory effects. Optimal scaling analysis indicated that hydroxycinnamic acids (quinic and chlorogenic), hydroxybenzoic acids (vanillic and syringic), flavonoids (quercetin and kaempferol), dihydrochalcones (neohesperidin) and flavones (acacetin) are related to the antioxidant activity of quince. While phenolic acids, flavonols (kaempferol-3-O-glucoside and rutin) and flavanols (epicatechin) generated the anti-inflammatory effect by inhibiting 52.3% of the COX-2 enzyme. Therefore, a selective extraction of phenolic mix can reduce oxidative stress or inflammatory processes. This suggests the use of quince as a natural source with significant nutraceutical potential.
PB MPDI
SN 1420-3049
YR 2022
FD 2022-04-11
LK https://hdl.handle.net/20.500.14352/71817
UL https://hdl.handle.net/20.500.14352/71817
LA eng
NO Herrera Rocha, K. M., Rocha Guzmán, N. E., Gallegos Infante, J. A. et al. «Phenolic Acids and Flavonoids in Acetonic Extract from Quince (Cydonia Oblonga Mill.): Nutraceuticals with Antioxidant and Anti-Inflammatory Potential». Molecules, vol. 27, n.o 8, abril de 2022, p. 2462. DOI.org (Crossref), https://doi.org/10.3390/molecules27082462.
DS Docta Complutense
RD 11 abr 2025