RT Journal Article T1 Analyzing the Performance Portability of SYCL across CPUs, GPUs, and Hybrid Systems with SW Sequence Alignment A1 Costanzo, Manuel A1 Rucci, Enzo A1 García, Carlos A1 Naiouf, Marcelo A1 Prieto Matías, Manuel AB The high-performance computing (HPC) landscape is undergoing rapid transformation, with an increasing emphasis on energy-efficient and heterogeneous computing environments. This comprehensive study extends our previous research on SYCL's performance portability by evaluating its effectiveness across a broader spectrum of computing architectures, including CPUs, GPUs, and hybrid CPU-GPU configurations from NVIDIA, Intel, and AMD. Our analysis covers single-GPU, multi-GPU, single-CPU, and CPU-GPU hybrid setups, using two common, bioinformatic applications as a case study. The results demonstrate SYCL's versatility across different architectures, maintaining comparable performance to CUDA on NVIDIA GPUs while achieving similar architectural efficiency rates on AMD and Intel GPUs in the majority of cases tested. SYCL also demonstrated remarkable versatility and effectiveness across CPUs from various manufacturers, including the latest hybrid architectures from Intel. Although SYCL showed excellent functional portability in hybrid CPU-GPU configurations, performance varied significantly based on specific hardware combinations. Some performance limitations were identified in multi-GPU and CPU-GPU configurations, primarily attributed to workload distribution strategies rather than SYCL-specific constraints. These findings position SYCL as a promising unified programming model for heterogeneous computing environments, particularly for bioinformatic applications. PB Elsevier YR 2025 FD 2025 LK https://hdl.handle.net/20.500.14352/119576 UL https://hdl.handle.net/20.500.14352/119576 LA eng DS Docta Complutense RD 24 dic 2025