RT Journal Article
T1 Hemodiafiltration with endogenous reinfusion improved microinflammation and endothelial damage compared with online-hemodiafiltration: a hypothesis generating study
A1 Esquivias Motta, Elvira
A1 Martín Malo, Alejandro
A1 Buendía, Paula
A1 Álvarez Lara, María A.
A1 Soriano, Sagrario
A1 Crespo, Rodolfo
A1 Carracedo Añón, Julia María
A1 Ramírez, Rafael
A1 Aljama, Pedro
AB Hemodiafiltration with endogenous reinfusion (HFR) after ultrafiltrate passage through a resin cartridge combines adsorption, convection, and diffusion. Our prospective single-center crossover study compared HFR and online-hemodiafiltration (OLHDF) effects on two uremic toxins and 13 inflammatory, endothelial status, or oxidative stress markers.After an 8-week run-in period of high-flux hemodialysis, 17 eligible stable dialysis patients (median age 65 years, 10 male) without overt clinical inflammation were scheduled for four 8-week periods in the sequence: HFR/OLHDF/HFR/OLHDF.Relative to OLHDF, HFR was associated with greater indoxyl sulfate removal and lesser abnormalities in all other study variables, namely circulating interleukin-6, tumor necrosis factor-alpha, proportions of activated proinflammatory (CD14+CD16+, CD14++CD16+) monocytes, endothelial progenitor cells, apoptotic endothelial microparticles, vascular endothelial growth factor, vascular cellular adhesion molecule, angiopoietins 2 and 1, annexin V, and superoxide dismutase. Differences were significant (P < 0.05) in median values of 13/15 variables. Study period comparisons were generally consistent with dialysis technique comparisons, as were data from the subgroup completing all study periods (n = 9).Our investigation provides hypothesis-generating results suggesting that compared with OLHDF, HFR improves protein-bound toxin removal, inflammatory and endothelial status, and oxidative stress.
PB Wiley
SN 0160-564X
YR 2016
FD 2016-05
LK https://hdl.handle.net/20.500.14352/131224
UL https://hdl.handle.net/20.500.14352/131224
LA eng
NO Esquivias-Motta E, Martín-Malo A, Buendia P, Álvarez-Lara MA, Soriano S, Crespo R, Carracedo J, Ramírez R, Aljama P. Hemodiafiltration With Endogenous Reinfusion Improved Microinflammation and Endothelial Damage Compared With Online-Hemodiafiltration: A Hypothesis Generating Study: Thoughts and Progress. Artificial Organs 2017;41:88–98. https://doi.org/10.1111/aor.12704.
NO Acknowledgments:This work was supported by Plan Nacional Proyectos de Investigación en Salud of Instituto de Salud Carlos III (ISCIII) Fondos Feder Grants (PI10/00960, PI11/01536, PI12/01489, and PI14/00806); Junta de Andalucía Grants (P010-CTS-6337, P11-CTS-7352); Fundación Nefrológica and an unrestricted grant from Bellco S.r.l., Mirandola, Italy. Julia Carracedo was supported by a contract from Fundación de Investigaciones Biomédicas de Córdoba (Servicio Andaluz de Salud, Programa Nicolás Monardes).
NO European Commission
NO Instituto de Salud Carlos III (España)
NO Junta de Andalucía
NO Fundación Nefrológica de Córdoba
NO Fundación de Investigaciones Biomédicas de Córdoba
NO Bellco
DS Docta Complutense
RD 24 mar 2026