RT Journal Article
T1 Genomic Plasticity of Vibrio cholerae.
A1 Escudero García-Calderón, José Antonio
A1 Mazel, Didier
AB Vibrio cholerae is one of the deadliest pathogens in the history of humankind. It is the causative agent of cholera, a disease characterized by a profuse and watery diarrhoea that still today causes 95.000 deaths worldwide every year. V. cholerae is a free living marine organism that interacts with and infects a variety of organisms, from amoeba to humans, including insects and crustaceans. The complexity of the lifestyle and ecology of V. cholerae suggests a high genetic and phenotypic plasticity. In this review, we will focus on two peculiar genomic features that enhance genetic plasticity in this bacterium: the division of its genome in two different chromosomes and the presence of the superintegron, a gene capture device that acts as a large, low-cost memory of adaptive functions, allowing V. cholerae to adapt rapidly.
PB Springer
SN 1139-6709
YR 2017
FD 2017-09
LK https://hdl.handle.net/20.500.14352/19290
UL https://hdl.handle.net/20.500.14352/19290
LA eng
NO Unión Europea. FP7
NO Comunidad de Madrid
NO Centre National de la Recherche Scientifique/Institut Pasteur
NO French National Research Agency
DS Docta Complutense
RD 20 may 2024