RT Journal Article
T1 Inflammatory Biomarkers in the Short-Term Prognosis of Venous Thromboembolism: A Narrative Review
A1 Galeano Valle, Francisco
A1 Ordieres Ortega, Lucía
A1 Oblitas, Crhistian Mario
A1 Toro Cervera, Jorge Del
A1 Álvarez-Sala Walther, Luis Antonio
A1 Demelo Rodríguez, Pablo
AB The relationship between inflammation and venous thrombosis is not well understood. An inflammatory response may be both the cause and consequence of venous thromboembolism (VTE). In fact, several risk factors of VTE modulate thrombosis through inflammatory markers. Acute pulmonary embolism (PE) is burdened by a remarkable mortality rate, up to 34% in severely ill patients presenting with hemodynamic instability. Initial mortality risk stratification is based on hemodynamic instability. Patients with a situation of hemodynamic stability require immediate further risk assessment based on clinical, imaging, and circulating biomarkers, as well as the presence of comorbidities. Some inflammatory biomarkers have shown potential usefulness in the risk stratification of patients with VTE, especially acute PE. C-reactive protein on admission is associated with 30-day mortality and bleeding in VTE patients. P-selectin is associated with right ventricle dysfunction in PE patients and might be associated with VTE recurrences and the extension of thrombosis. Tissue factor microparticles are associated with VTE recurrence in cancer-associated thrombosis. Other inflammatory biomarkers present scarce evidence (inflammatory cytokines, erythrocyte sedimentation rate, fibrinogen, leukocyte count). In this manuscript, we will review the prognostic role of different inflammatory biomarkers available both for clinical practice and research in VTE patients.
PB MPDI
SN 1422-0067
YR 2021
FD 2021-03-05
LK https://hdl.handle.net/20.500.14352/7052
UL https://hdl.handle.net/20.500.14352/7052
LA eng
NO Galeano Valle, F., Ordieres Ortega, L., Oblitas, C. M. et al. «Inflammatory Biomarkers in the Short-Term Prognosis of Venous Thromboembolism: A Narrative Review». International Journal of Molecular Sciences, vol. 22, n.o 5, marzo de 2021, p. 2627. DOI.org (Crossref), https://doi.org/10.3390/ijms22052627.
DS Docta Complutense
RD 10 abr 2025