RT Journal Article T1 Coronary microvascular dysfunction is associated with impaired cognitive function: the Cerebral-Coronary Connection study (C3 study) A1 Mejía Rentería, Hernán A1 Travieso, Alejandro A1 Yus, Miguel A1 Espejo Paeres, Carolina A1 Finocchiaro, Francesca A1 Gómez-Escalonilla, Carlos Ignacio A1 Gómez Garre, María Dulce Nombre A1 Gómez de Diego, José Juan A1 Modrego Martín, Javier A1 Ortega Hernández, Adriana A1 Papadopoulos, Petros A1 Matías-Guiu Guía, Jorge A1 Escaned Barbosa, Javier A1 Arrazola García, Juan Lorenzo A1 Pérez De Isla, Leopoldo A1 Bustos García De Castro, Ana María A1 Delgado Álvarez, Alfonso A1 Reneses Prieto, Blanca María Asunción A1 Fernández Guinea, Sara Belén AB Background It remains unknown whether the presence of coronary microcirculatory dysfunction (CMD) correlates with its equivalent conditionin the brain, cerebral small vessel disease (CSVD). The cerebral-coronary connection (C3), a prospective blinded study, investigatedthe prevalence of CMD in patients with coronary artery disease (CAD) and its association with CSVD and cognitive function.Methodsand resultsPatients with documented CAD fulfilling inclusion criteria underwent physiological assessment of epicardial vessels and the microcirculation using intracoronary pressure and Doppler. Coronary microcirculation-related indices included coronary flow reserve (CFR) and hyperaemic microvascular resistance. Brain magnetic resonance imaging, transcranial Doppler (TCD), and neurocognitive examination were performed. Overall, 67 patients were included in the study (mean age 66 years, 73% female). Patients with abnormal CFR (<2.0) (55.2%) showed higher burden of white-matter hyperintensities: 43.2 vs. 20.0% (P=0.044). After statistical adjustment, low CFR was associated with lower grey matter volume (P=0.024) and with parameters of white-matter microstructural damage in diffusion-tensor imaging (lower fractional anisotropy and higher mean diffusivity, P=0.029 and P=0.032, respectively). Low CFR was associated with higher resistive (P=0.027) and pulsatility (P=0.043) values on TCD, and worse neurocognitive test scores (lower mini mental state examination, P=0.025, and slower Trail Making Test A, P=0.034).Conclusions Coronary microcirculatory dysfunction is frequent in patients with CAD and correlates with CSVD, abnormal cerebral flow haemodynamics, and significant cognitive impairment. These findings support the hypothesis that microvascular dysfunction in the heart and the brain are part of a single pathological process affecting microcirculation in patients with CAD. SN 0195-668X SN 1522-9645 YR 2022 FD 2022-11-07 LK https://hdl.handle.net/20.500.14352/99915 UL https://hdl.handle.net/20.500.14352/99915 LA eng NO Mejia Renteria, H., Travieso, A., Yus, M. et al. «Coronary Microvascular Dysfunction Is Associated with Impaired Cognitive Function: The Cerebral-Coronary Connection Study (C3 Study)». European Heart Journal, vol. 44, n.o 2, enero de 2023, pp. 113-25. DOI.org (Crossref), https://doi.org/10.1093/eurheartj/ehac521. DS Docta Complutense RD 8 abr 2025