RT Journal Article
T1 Antiviral Activity of Self‐Assembled Glycodendro[60]fullerene  Monoadducts
A1 Muñoz, Antonio
A1 Illescas Martínez, Beatriz María
A1 Luczkowiak, Joanna
A1 Lasala, Fátima
A1 Ribeiro Viana, Renato
A1 Rojo, Javier
A1 Delgado Vázquez, Rafael
A1 Martín León, Nazario
AB A  series  of  amphiphilic  glycodendro[60]fullerene  monoadducts  were  efficiently  synthesized  using  the  CuAAC  “click  chemistry” approach. These glycodendrofullerenes can self‐assemble in aqueous media, in a process favoured through π‐  π  interactions  between  the  [60]fullerene  moieties.  This  aggregation  process  leads  to  big  and  well‐defined  compact  micelles  with  a  uniform  size  and  spherical‐shape.  The  supramolecular  aggregate  was  characterized  using  electronic  microscopy  (SEM  and  TEM),  light  scattering  methods  (DLS)  and  X‐ray  methodologies  (SAXS  and  XRD).  The  antiviral  efficiency of these aggregates has been tested in an experimental infection assay using Ebola virus glycoprotein (EboGP)  pseudotyped viral  particles  on  Jurkat  cells  overexpressing DC‐SIGN and it is  observed an improvement  of  the IC50 value  with respect to other systems endowed with a higher number of carbohydrate ligands.
PB RSC
SN 2050-750X
YR 2017
FD 2017-06-12
LK https://hdl.handle.net/20.500.14352/18415
UL https://hdl.handle.net/20.500.14352/18415
LA eng
NO Muñoz, A., Illescas Martínez, B. M., Luczkowiak, J. et al. «Antiviral Activity of Self-Assembled Glycodendro[60]Fullerene Monoadducts». Journal of Materials Chemistry B, vol. 5, n.o 32, 2017, pp. 6566-71. DOI.org (Crossref), https://doi.org/10.1039/C7TB01379E.
NO Unión Europea
NO Ministerio de Economía, Comercio y Empresa (España)
NO Comunidad de Madrid
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 7 abr 2025