TY  - JOUR
AU  - Marín Ramos, Nagore Isasbel
AU  - Balabasquer Peña, Moisés
AU  - Ortega Nogales, Francisco Jesús
AU  - Torrecillas, Iván R.
AU  - Gil Ordóñez, Ana
AU  - Marcos Ramiro, Beatriz
AU  - Aguilar Garrido, Pedro
AU  - Cushman, Ian
AU  - Romero, Antonio
AU  - Medrano, Francisco J.
AU  - Gajate Fraile, Consuelo
AU  - Mollinedo García, Faustino
AU  - Philips, Mark R.
AU  - Campillo, Mercedes
AU  - Gallardo Delgado, Miguel
AU  - Martín-Fontecha Corrales, María Del Mar
AU  - López Rodríguez, María Luz
AU  - Ortega Gutiérrez, Silvia
PY  - 2019
DO  - 10.1021/acs.jmedchem.9b00145
SN  - 0022-2623
UR  - https://hdl.handle.net/20.500.14352/13701
T2  - Journal of Medicinal Chemistry
AB  - Blockade of Ras activity by inhibiting its post-translational methylation catalyzed by isoprenylcysteine carboxylmethyltransferase (ICMT) has been suggested as a promising antitumor strategy. However, the paucity of inhibitors has precluded the...
LA  - eng
M2  - 6035
PB  - American chemical Society (ACS)
KW  - Small-molecule inhibitors
KW  - Oncogenic k-ras
KW  - Carboxyl methyltransferase
KW  - Antitumor-activity
KW  - Cell-death Mechanism
KW  - Apoptosis
KW  - Farnesyl
KW  - Farnesyltrastransferase
KW  - Prenylation
KW  - Prenylated proteins
KW  - ICMT
KW  - Myeloid leukemia
TI  - A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia
TY  - journal article
VL  - 62
ER  -