RT Journal Article
T1 N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo
A1 Morales García, José Ángel
A1 Calleja Conde, Javier
A1 López Moreno, José Antonio
A1 Alonso Gil, Sandra
A1 Sanz SanCristobal, Marina
A1 Riba, Jordi
A1 Pérez Castillo, Ana
AB N,N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally used for ritual and therapeutic purposes across several South American countries. Here, we have examined, in vitro and vivo, the potential neurogenic effect of DMT. Our results demonstrate that DMT administration activates the main adult neurogenic niche, the subgranular zone of the dentate gyrus of the hippocampus, promoting newly generated neurons in the granular zone. Moreover, these mice performed better, compared to control non-treated animals, in memory tests, which suggest a functional relevance for the DMT-induced new production of neurons in the hippocampus. Interestingly, the neurogenic effect of DMT appears to involve signaling via sigma-1 receptor (S1R) activation since S1R antagonist blocked the neurogenic effect. Taken together, our results demonstrate that DMT treatment activates the subgranular neurogenic niche regulating the proliferation of neural stem cells, the migration of neuroblasts, and promoting the generation of new neurons in the hippocampus, therefore enhancing adult neurogenesis and improving spatial learning and memory tasks.
PB Springer Nature
SN 2158-3188
YR 2020
FD 2020-09-28
LK https://hdl.handle.net/20.500.14352/111051
UL https://hdl.handle.net/20.500.14352/111051
LA eng
NO Morales-Garcia, J.A., Calleja-Conde, J., Lopez-Moreno, J.A. et al. N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo. Transl Psychiatry 10, 331 (2020). https://doi.org/10.1038/s41398-020-01011-0
DS Docta Complutense
RD 31 dic 2025