RT Journal Article
T1 Decoration of Squalenoyl‐Gemcitabine Nanoparticles with Squalenyl‐Hydroxybisphosphonate for the Treatment of Bone Tumors
A1 Rodríguez‐Nogales, Carlos
A1 Desmaële, Didier
A1 Sebastián, Víctor
A1 Couvreur, Patrick
A1 Blanco‐Prieto, María J.
AB Therapeutic perspectives of bone tumors such as osteosarcoma remain restricted due to the inefficacy of current treatments. We propose here the construction of a novel anticancer squalene-based nanomedicine with bone affinity and retention capacity. A squalenyl-hydroxybisphosphonate molecule was synthetized by chemical conjugation of a 1-hydroxyl-1,1-bisphosphonate moiety to the squalene chain. This amphiphilic compound was inserted onto squalenoyl-gemcitabine nanoparticles using the nanoprecipitation method. The co-assembly led to nanoconstructs of 75 nm, with different morphology and colloidal properties. The presence of squalenyl-hydroxybi-sphosphonate enhanced the nanoparticles binding affinity for hydroxyapatite, a mineral present in the bone. Moreover, the in vitro anticancer activity was preserved when tested in commercial and patient-treated derived pediatric osteosarcoma cells. Further in vivo studies will shed light on the potential of these nanomedicines for the treatment of bone sarcomas.
PB Wiley
SN 1860-7179
SN 1860-7187
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/132893
UL https://hdl.handle.net/20.500.14352/132893
LA eng
NO Rodríguez‐Nogales C, Desmaële D, Sebastián V, et al. Decoration of Squalenoyl‐Gemcitabine Nanoparticles with Squalenyl‐Hydroxybisphosphonate for the Treatment of Bone Tumors. ChemMedChem 2021;16:3730–8. https://doi.org/10.1002/cmdc.202100464
NO Asociación Española Contra el Cáncer
NO Fundación Caja Navarra
NO Obra Social La Caixa
NO Instituto de Salud Carlos III (España)
NO European Commission
DS Docta Complutense
RD 26 feb 2026