RT Journal Article
T1 Lipoprotein alterations in patients with HIV infection: relation with cellular and humoral immune markers
A1 Fernández Miranda, Consuelo
A1 Pulido Ortega, Federico
A1 Carrillo, Juan L.
A1 Larumbe, Sagrario
A1 Gómez Izquierdo, Teresa
A1 Ortuño, Blanca
A1 Rubio García, Rafael
A1 del Palacio, Ángel
AB In order to determine lipid abnormalities in serum in HIV-infected patients and their relation with humoral and cellular immunological changes. Ninety HIV-infected patients without acute inflammatory or malignant disease have been studied. Thirty healthy HIV-negative subjects constituted the control group. As compared with controls, patients with CD4 + lymphocytes > 400 x 10(6)/l had higher triglycerides and lower high density lipoprotein (HDL)-cholesterol and apolipoprotein (apo)-A1. Lipoprotein comparison by groups of patients according to CD4 + cell counts showed a decrease of HDL-cholesterol in patients with CD4 + cells < or = 200 x 10(6)/l. When CD4 + lymphocyte counts were < 50 x 10(6)/l, total and very low density lipoprotein (VLDL)-triglycerides and VLDL-cholesterol were increased and HDL and low density lipoprotein (LDL)-cholesterol and apo-A1 were decreased. Interferon (IFN)-alpha, beta2-microglobulin and tumor necrosis factor (TNF)-alpha were correlated positively with total and VLDL-triglycerides and negatively with HDL-cholesterol. In conclusion, lipoprotein changes in patients with HIV-infection are related with humoral and cellular immune markers. A decrease of HDL-cholesterol and apo-A1 and an increase of triglyceride levels could be considered as markers of disease progression.
PB Elsevier
SN 0009-8981
YR 1998
FD 1998-06-08
LK https://hdl.handle.net/20.500.14352/107332
UL https://hdl.handle.net/20.500.14352/107332
LA eng
NO Fernández-Miranda C, Pulido F, Carrillo JL, Larumbe S, Gómez Izquierdo T, Ortuño B, Rubio R, del Palacio A. Lipoprotein alterations in patients with HIV infection: relation with cellular and humoral immune markers. Clin Chim Acta. 1998 Jun 8;274(1):63-70
DS Docta Complutense
RD 22 abr 2025