RT Journal Article
T1 A diet based on cured acorn-fed ham with oleic acid content promotes antiinflammatory gut microbiota and prevents ulcerative colitis in an animal model
A1 Fernández Castillo, Jesús
A1 García de la Fuente, V.
A1 Fernández García, M. T.
A1 Gómez Sánchez, J.
A1 Isabel Redondo, Beatriz
A1 Villar, C. J.
A1 Lombó, F.
A2 Springer Nature, 
AB Background: Diets based on meat products are not recommended in the case of ulcerative colitis (UC). The objective here is to test if some traditional cured meat products, as acorn-fed ham (high levels of oleic acid), may be useful for controlling inflammatory diseases as UC in animal models, which could represent a new dietary complementary intervention in the prevention of this inflammatory disease in humans. Methods: Two rat cohorts have been used: conventional vegetable rat feed and acorn-fed ham. UC was induced with DSS in drinking water ad libitum for 1 week. Short-chain fatty acids (SCFAs) and 16S rRNA metagenomics from bacterial populations were analyzed in cecum samples. Colon samples were analyzed for histological parameters. Results: Acorn-fed ham diet induced changes in gut microbiota composition, with pronounced enrichments in anti-inflammatory bacterial genera (Alistipes, Blautia, Dorea, Parabacteroides). The animals with this diet showed a strong reduction in most parameters associated to ulcerative colitis: disease activity index, macroscopic score of colitis, epitelium alteration in colon mucosa, inflammatory cell density in colon, myeloperoxidase titers in colon, proinflammatory cytokines (IL-17, IFN-γ). Also, acorn-fed ham diet animals showed increased total antioxidant activity an oleic acid levels in plasma, as well as higher short-chain fatty acid concentrations in cecum (isobutyric, isovaleric and valeric). Conclusions: In the acorn-fed ham cohort, as a result of the dietary intake of oleic acid and low intake of omega-6 fatty acids, a strong preventive effect against UC symptoms was observed. Keywords: Oleic acid, Acorn-fed ham, Gut microbiota, Ulcerative colitis, Antiiflammatory
PB Springer Nature
YR 2020
FD 2020-02-24
LK https://hdl.handle.net/20.500.14352/98575
UL https://hdl.handle.net/20.500.14352/98575
LA eng
NO A diet based on cured acorn-fed ham with oleic acid content promotes antiinflammatory gut microbiota and prevents ulcerative colitis in an animal model J. Fernández1,2,3, V. García de la Fuente3,4, M. T. Fernández García3,4, J. Gómez Sánchez4,5, B. Isabel Redondo5,6, C. J. Villar1,2,3 and F. Lombó1,2,3*
NO Cárnicas Joselito SA (FUO-222-16)
NO Universidad de Oviedo y Universidad Complutense de Madrid (IDI/2018/000120) - Programa de Ayudas a Grupos de Investigación del Principado de Asturias.
DS Docta Complutense
RD 3 abr 2025