RT Journal Article
T1 Mimicking Peroxidase Activities with Prussian Blue Nanoparticles and Their Cyanometalate Structural Analogues
A1 Vázquez González, Margarita
A1 Torrente Rodríguez, Rebeca M.
A1 Kozell, Anna
A1 Liao, Wei-Ching
A1 Cecconello, Alessandro
A1 Campuzano, Susana
A1 Pingarrón Carrazón, José Manuel
A1 Willner, Itamar
AB Nanoparticles composed of Prussian Blue, PB, and the cyanometalate structural analogues, CuFe, FeCoFe, and FeCo, are examined as inorganic clusters that mimic the functions of peroxidases. PB acts as a superior catalyst for the oxidation of dopamine to aminochrome by H2O2. The oxidation of dopamine by H2O2 in the presence of PB is 6-fold faster than in the presence of CuFe. The cluster FeCo does not catalyze the oxidation of dopamine to aminochrome. The most efficient catalyst for the generation of chemiluminescence by the oxidation of luminol by H2O2 is, however, FeCo, and PB lacks any catalytic activity toward the generation of chemiluminescence. The order of catalyzed chemiluminescence generation is FeCo ≫ CuFe > FeCoFe. The clusters PB, CuFe, FeCoFe, and FeCo mimic the functions of NADH peroxidase. The catalyzed oxidation of NADH by H2O2 to form NAD+ follows the order PB ≫ CuFe ∼ FeCoFe, FeCo. The efficient generation of chemiluminescence by the FeCo-catalyzed oxidation of luminol by H2O2 is used to develop a glucose sensor. The aerobic oxidation of glucose in the presence of glucose oxidase, GOx, yields gluconic acid and H2O2. The chemiluminescence intensities formed by the GOx-generated H2O2 relate to the concentration of glucose, thus providing a quantitative readout signal for the concentrations of glucose.
PB ACS
SN (Print)1530-6984 (On line)1530-6992
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/18077
UL https://hdl.handle.net/20.500.14352/18077
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
DS Docta Complutense
RD 20 ago 2024