%0 Journal Article
%A Legarda Ceballos, Ana L.
%A del Olmo, Esther
%A López-Abán, Julio
%A Escarcena, Ricardo
%A Bustos, Luis A.
%A Fonseca Berzal, Cristina Rosa
%A Gómez Barrio, Alicia
%A Dib, Juan
%A San Feliciano, Arturo
%A Muro, Antonio
%T Trypanocidal Activity of Long Chain Diamines and Aminoalcohols
%D 2015
%@ 1420-3049
%U https://hdl.handle.net/20.500.14352/23897
%X Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0–6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigotes of the CL-B5 strain (IC50 = 0.6 µM), with a selectivity index of 54.
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