RT Journal Article
T1 Trypanocidal Activity of Long Chain Diamines and Aminoalcohols
A1 Legarda Ceballos, Ana L.
A1 del Olmo, Esther
A1 López-Abán, Julio
A1 Escarcena, Ricardo
A1 Bustos, Luis A.
A1 Fonseca Berzal, Cristina Rosa
A1 Gómez Barrio, Alicia
A1 Dib, Juan
A1 San Feliciano, Arturo
A1 Muro, Antonio
AB Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0–6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigotes of the CL-B5 strain (IC50 = 0.6 µM), with a selectivity index of 54.
PB MDPI
SN 1420-3049
YR 2015
FD 2015-06-23
LK https://hdl.handle.net/20.500.14352/23897
UL https://hdl.handle.net/20.500.14352/23897
LA eng
NO Junta de Castilla y León
NO Instituto de Salud Carlos III (ISCIII)/FIS
NO Universidad de Salamanca
NO Campus de Excelencia Internacional Moncloa
DS Docta Complutense
RD 26 feb 2026