RT Journal Article
T1 Genipin as An Emergent Tool in the Design of Biocatalysts: Mechanism of Reaction and Applications
A1 Tacias-Pascacio, Veymar G.
A1 García-Parra, Esmeralda
A1 Vela-Gutiérrez, Gilber
A1 Virgen-Ortiz, Jose J.
A1 Berenguer-Murcia, Ángel
A1 Alcántara León, Andrés Rafael
A1 Fernandez-Lafuente, Roberto
AB Genipin is a reagent isolated from the Gardenia jasminoides fruit extract, and whose low toxicity and good crosslinking properties have converted it into a reactive whose popularity is increasing by the day. These properties have made it widely used in many medical applications, mainly in the production of chitosan materials (crosslinked by this reactive), biological scaffolds for tissue engineering, and nanoparticles of chitosan and nanogels of proteins for controlled drug delivery, the genipin crosslinking being a key point to strengthen the stability of these materials. This review is focused on the mechanism of reaction of this reagent and its use in the design of biocatalysts, where genipin plays a double role, as a support activating agent and as inter- or intramolecular crosslinker. Its low toxicity makes this compound an ideal alterative to glutaraldehyde in these processes. Moreover, in some cases the features of the biocatalysts prepared using genipin surpassed those of the biocatalysts prepared using other standard crosslinkers, even disregarding toxicity. In this way, genipin is a very promising reagent in the design of biocatalysts.
PB MDPI
SN 2073-4344
YR 2019
FD 2019-12-06
LK https://hdl.handle.net/20.500.14352/8313
UL https://hdl.handle.net/20.500.14352/8313
LA eng
NO Ministerio de Economía y Competitividad (MINECO)/FEDER
NO Ministerio de Ciencia e Innovación (MICINN)
NO Generalitat Valenciana
NO Consejo Nacional de Ciencia y Tecnología (CONACYT) de México
DS Docta Complutense
RD 8 abr 2025