RT Journal Article T1 Neighborhood vulnerability and disability in first episode of psychosis: a multi level study A1 Izquierdo Zarzo, Ana A1 Muñoz Madrigal, José Luis A1 Mac-Dowell Mata, Karina Soledad A1 Rodríguez Jiménez, Roberto A1 Rentero, David A1 Ayora, Miriam A1 Martínez Díaz-Caneja, María Covadonga A1 Abregú Crespo, Renzo A1 Mellor Marsá, Blanca A1 Díaz Marsa, Marina Francisca A1 Ayuso Mateos, José Luis AB Objective: Neighborhood socioeconomic status seems to be related to functioning in patients with first episode of psychosis (FEP). The present study aimed to assess if neighborhood vulnerability and risk of social exclusion could predict functional outcomes in people with FEP after controlling for other key variables identified in previous literature.Methods: A total of 137 patients with FEP (DSM-IV-TR criteria) and 90 controls comprised the study sample from February 2013 to May 2019. Functioning was assessed with the WHO Disability Assessment Schedule. Neighborhood vulnerability was measured using a multidimensional socioeconomic deprivation index; data for the index were collected by the Madrid City Council and based on the participant's home address. Multilevel mixed-effects regression analyses were conducted to estimate the effects of neighborhood vulnerability on functioning.Results: Our results show that FEP patients could be more vulnerable to the effects of neighborhood-level characteristics than healthy controls (B = 1,570.173; z = 3.91; P < .001). In addition, our findings suggest that higher neighborhood vulnerability is related to greater functional disability in people with FEP, after controlling for other relevant confounders (B = 1,230.332; z = 2.59; P = .010).Conclusions: These results highlight the importance of incorporating contextual factors into assessment of patients with FEP, since psychosocial difficulties observed in these patients could be partially related to the quality of neighborhood social-related resources. PB Physicians Postgraduate Press SN 0160-6689 YR 2023 FD 2023-03-01 LK https://hdl.handle.net/20.500.14352/110001 UL https://hdl.handle.net/20.500.14352/110001 LA eng NO Izquierdo A, Cabello M, Leal I, Torio I, Madrigal JLM, MacDowell KS, Rodriguez-Jimenez R, Rentero D, Ibáñez Á, Ayora M, Díaz-Caneja CM, Abregú-Crespo R, Mellor-Marsá B, Díaz-Marsá M, Malpica N, Bravo-Ortiz MF, Baca-García E, Arango C, Ayuso-Mateos JL; AGES-CM Group. Neighborhood Vulnerability and Disability in First Episode of Psychosis: A Multilevel Study. J Clin Psychiatry. 2023 Mar 13;84(2):22m14401. doi: 10.4088/JCP.22m14401 DS Docta Complutense RD 18 abr 2025