RT Journal Article
T1 Ocular Involvement in Friedreich Ataxia Patients and its Relationship with Neurological Disability, a Follow-up Study
A1 Rojas Lozano, María Del Pilar
A1 Ramírez Sebastián, Ana Isabel
A1 Hoz Montañana, María Rosa De
A1 Cadena Santoyo, Manuel
A1 Ferreras Amez, Antonio
A1 Monsalve Córdova, Blanca
A1 García Martín, Elena Salobrar
A1 Muñóz Blanco, José L.
A1 Urcelay Segura, José Luis
A1 Salazar Corral, Juan José
A1 Ramírez Sebastián, José Manuel
AB Background: This study compared functional and structural visual changes in Friedreich ataxia (FRDA) patients with healthy controls (HC) and correlated these changes with neurological disability. Methods: Eight FRDA Spanish patients and eight HC were selected from 2014 to 2018. Best corrected visual acuity (BCVA), visual field (VF), optic coherence tomography (OCT), and neurological disability measured by “scale for the assessment and rating of ataxia” (SARA) were taken in a basal exploration and repeated after 6 months. A linear mixed analysis and Bonferroni p-value correction were performed. Results: FRDA baseline and follow-up patients showed statistically significant decreases in BCVA, VF, and OCT parameters compared with the HC. Some of the VF measurements and most of the OCT parameters had an inverse mild-to-strong correlation with SARA. Moreover, the analysis of the ROC curve demonstrated that the peripapillary retinal nerve fiber layer (pRNFL) average thickness was the best parameter to discriminate between FRDA patients and HC. Conclusions: The follow-up study showed a progression in OCT parameters. Findings showed a sequential effect in pRNFL, ganglion cell complex (GCC), and macula. The VF and the OCT could be useful biomarkers in FRDA, both for their correlation with neurological disease as well as for their ability to evaluate disease progression.
PB MDPI
SN 2075-4418
YR 2020
FD 2020-01-29
LK https://hdl.handle.net/20.500.14352/6042
UL https://hdl.handle.net/20.500.14352/6042
LA eng
NO Rojas Lozano, P., Ramírez Sebastián, A. I., Hoz Momtañana, M. R. et al. «Ocular Involvement in Friedreich Ataxia Patients and Its Relationship with Neurological Disability, a Follow-Up Study». Diagnostics, vol. 10, n.o 2, enero de 2020, p. 75. DOI.org (Crossref), https://doi.org/10.3390/diagnostics10020075.
NO (This article belongs to the Section Pathology and Molecular Diagnostics)Received: 24 December 2019 / Revised: 28 January 2020 / Accepted: 29 January 2020 / Published: 29 January 2020
DS Docta Complutense
RD 22 abr 2025