RT Journal Article
T1 Proanthocyanidins: Impact on Gut Microbiota and Intestinal Action Mechanisms in the Prevention and Treatment of Metabolic Syndrome
A1 Redondo-Castillejo, Rocío
A1 Garcimartín Álvarez, Alba
A1 Hernández Martín, Marina
A1 López-Oliva Muñoz, María Elvira
A1 Bocanegra De Juana, Aranzazu
A1 Macho González, Adrián
A1 Bastida Codina, Sara
A1 Benedí González, Juana María
A1 Sánchez Muniz, Francisco José
AB The metabolic syndrome (MS) is a cluster of risk factors, such as central obesity, hyperglycemia, dyslipidemia, and arterial hypertension, which increase the probability of causing premature mortality. The consumption of high-fat diets (HFD), normally referred to high-saturated fat diets, is a major driver of the rising incidence of MS. In fact, the altered interplay between HFD, microbiome, and the intestinal barrier is being considered as a possible origin of MS. Consumption of proanthocyanidins (PAs) has a beneficial effect against the metabolic disturbances in MS. However, there are no conclusive results in the literature about the efficacy of PAs in improving MS. This review allows a comprehensive validation of the diverse effects of the PAs on the intestinal dysfunction in HFD-induced MS, differentiating between preventive and therapeutic actions. Special emphasis is placed on the impact of PAs on the gut microbiota, providing a system to facilitate comparison between the studies. PAs can modulate the microbiome toward a healthy profile and strength barrier integrity. Nevertheless, to date, published clinical trials to verify preclinical findings are scarce. Finally, the preventive consumption of PAs in MS-associated dysbiosis and intestinal dysfunction induced by HFD seems more successful than the treatment strategy.
PB MDPI
SN 1661-6596
YR 2023
FD 2023-03-10
LK https://hdl.handle.net/20.500.14352/93075
UL https://hdl.handle.net/20.500.14352/93075
LA eng
NO Rocío Redondo-Castillejo, Alba Garcimartín, Marina Hernández-Martín, María Elvira López-Oliva, Aránzazu Bocanegra, Adrián Macho-González, Sara Bastida, Juana Benedí, Francisco J. Sánchez-Muniz. Proanthocyanidins: Impact on Gut Microbiota and Intestinal Action Mechanisms in the Prevention and Treatment of Metabolic Syndrome. International Journal of Molecular Sciences 2023, 24 (6) , 5369
NO Ministerio de Ciencia, Innovación y Universidades
DS Docta Complutense
RD 17 abr 2025