RT Journal Article
T1 The WIPI Gene Family and Neurodegenerative Diseases: Insights From Yeast and Dictyostelium Models
A1 Vincent, Olivier
A1 Antón Esteban, Laura
A1 Bueno Arribas, Miranda
A1 Tornero Écija, Alba
A1 Navas Hernández, María Ángeles
A1 Escalante, Ricardo
AB WIPIs are a conserved family of proteins with a characteristic 7-bladed β-propeller structure. They play a prominent role in autophagy, but also in other membrane trafficking processes. Mutations in human WIPI4 cause several neurodegenerative diseases. One of them is BPAN, a rare disease characterized by developmental delay, motor disorders, and seizures. Autophagy dysfunction is thought to play an important role in this disease but the precise pathological consequences of the mutations are not well established. The use of simple models such as the yeast Saccharomyces cerevisiae and the social amoeba Dictyostelium discoideum provides valuable information on the molecular and cellular function of these proteins, but also sheds light on possible pathways that may be relevant in the search for potential therapies. Here, we review the function of WIPIs as well as disease-causing mutations with a special focus on the information provided by these simple models.
PB Frontiers Media
SN 2296-634X
YR 2021
FD 2021-09-01
LK https://hdl.handle.net/20.500.14352/91413
UL https://hdl.handle.net/20.500.14352/91413
LA eng
NO Vincent O, Antón-Esteban L, Bueno-Arribas M, Tornero-Écija A, Navas M-Á and Escalante R (2021) The WIPI Gene Family and Neurodegenerative Diseases: Insights From Yeast and Dictyostelium Models. Front. Cell Dev. Biol. 9:737071. doi: 10.3389/fcell.2021.737071
NO Ministerio de Ciencia e Innovación
DS Docta Complutense
RD 8 abr 2025