RT Journal Article
T1 Liver and spleen volumes are associated with prognosis of compensated and decompensated cirrhosis and parallel its natural history
T2 
A1 Romero Cristóbal, Mario
A1 Clemente Sánchez, Ana
A1 Peligros Gómez, María Isabel
A1 Ramón, Enrique
A1 Matilla, Ana María
A1 Colón, Arturo
A1 Alonso, Sonia
A1 Vega Catalina, María
A1 Fernández Yunquera, Ainhoa
A1 Caballero, Aranzazu
A1 García Martínez, Rita
A1 López Baena, José Ángel
A1 Salcedo Plaza, María Magdalena
A1 Bañares Cañizares, Rafael
A1 Rincón Rodríguez, Diego
A1 Martínez Caballero, María Aranzazu
A2 , 
AB Cirrhosis is characterized by the complex interplay among biological, histological and haemodynamic events. Liver and spleen remodelling occur throughout its natural history, but the prognostic role of these volumetric changes is unclear. We evaluated the relationship between volumetric changes assessed by multidetector computerised tomography (MDCT) and landmark features of cirrhosis.Methods: We included consecutive cirrhotic patients who underwent liver transplantation (LT) or hepatocellular carcinoma (HCC) resection in whom dynamic MDCT was available. Different volumetric indices were calculated. Fibrosis was evaluated by the collagen proportional area and Laennec sub-stages. Correlation and logistic regression analysis were performed to explore associations of volumetric indexes and fibrosis with key prognostic features across the clinical stages of cirrhosis.Results: 185 patients were included (146 LT; 39 HCC); the predominant aetiology was viral hepatitis (51.35%); 65.9% had decompensated disease and 85.08% clinically significant portal hypertension (CSPH). The standardised liver volume and liver-spleen volume ratio negatively correlated with Model for End-stage Liver Disease (MELD), albumin and hepatic venous pressure gradient (HVPG) and were significantly lower in decompensated patients. The liver segmental volume ratio (segments I-III/segments IV-VIII) best captured the characteristic features of the compensated phase, showing a positive correlation with HVPG and a good discrimination between patients with and without CSPH and varices. Volumetric changes and fibrosis severity were independently associated with key prognostic events, with no association between these two parameters.Conclusions: Liver and spleen volumetric indices evolve differently along the natural history of cirrhosis and are associated with key prognostic factors in each phase, regardless of fibrosis severity and portal hypertension.
PB Wiley
YR 2022
FD 2022-10
LK https://hdl.handle.net/20.500.14352/110510
UL https://hdl.handle.net/20.500.14352/110510
LA eng
NO Romero-Cristóbal M, Clemente-Sánchez A, Peligros MI, Ramón E, Matilla AM, Colón A, Alonso S, Catalina MV, Fernández-Yunquera A, Caballero A, García R, López-Baena JÁ, Salcedo MM, Bañares R, Rincón D. Liver and spleen volumes are associated with prognosis of compensated and decompensated cirrhosis and parallel its natural history. United European Gastroenterol J. 2022 Oct;10(8):805-816. doi: 10.1002/ueg2.12301. Epub 2022 Sep 6. PMID: 36065767; PMCID: PMC9557954.
NO 
DS Docta Complutense
RD 5 abr 2025