%0 Journal Article
%A López Artero, Esther
%A Garzón Jiménez, Nuria
%A Rodríguez Vallejo, Manuel
%A García Montero, María
%T Feasibility of optical quality analysis system for the objetctive assessment of accommodation insufficiency: a phase 1 study
%D 2020
%@ 1888-4296
%U https://hdl.handle.net/20.500.14352/6427
%X Purpose: To assess differences in a new objective metric obtained with a double-pass technique between a group with accommodation insufficiency (AI) and a control group  and to explore the diagnostic capabilities of this new tool in comparison to  conventional procedures.Methods: Retrospective cross-sectional case-control phase 1 study. Two groups age  ranging from 8 to 18 years were recruitment: AI and control group. The diagnostic  criterion of AI was based on monocular accommodative amplitude (AA) 2 D below  Hofstetter’s calculation for minimum AA and monocular accommodative facility (MAF)  failing with minus lens and cut-off at ≤ 6 cycles per minute. Accommodative response  with a double pass device (HD Analyzer, Visiometrics) was measured, performing an  evaluation from +1.00 D to −3.50D (−0.5D steps), offering the width of the profile  at 50% (WP) in minutes of arc.Results: Differences were found between groups for the AA, MAF and MEM retinoscopy (p < 0.0001, p < 0.001, p = 0.037). The discriminative capacity of MEM retinoscopy  for AI diagnosis was significant and the cut-off that maximized the sensitivity and  specificity was > 0.5 D. Considering WP 50% in different points, the discriminative  AI diagnosis capacities for the points of 2.0 D and 2.50 D were significant (ROC-AUC  0.78; p = 0.03 and p = 0.02).Conclusions: Double-pass system metric differed between patients with AI and control  group, therefore the aim of a Phase I study was achieved. Further steps with higher  sample sizes are required to evidence if the system really provides any advantage  versus conventional methods in the diagnosis of AI.
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