RT Journal Article
T1 Correlation between in vitro and in vivo activity of levofloxacin and moxifloxacin against pneumococcal strains with different susceptibilities to fluoroquinolones
A1 Huelves, Lorena
A1 Sevillano Fernández, David
A1 Martínez-Marín, Carmina
A1 López-Casla, María Teresa
A1 Gracia, Matilde
A1 Alou Cervera, Luis
A1 Ponte, María del Carmen
A1 Prieto Prieto, José
A1 Soriano, Francisco
AB In vitro and in vivo models were developed to evaluate the efficacy of levofloxacin and moxifloxacin against three serotype 3 pneumococcal strains with different susceptibilities to fluoroquinolones (wild-type, parC mutant, and parC, parE and gyrA mutant). Levofloxacin and moxifloxacin reduced the bacterial burden in the in vitro pharmacodynamic and animal models for the wild-type strain but had very little activity against the fully resistant strain (parC, parE and gyrA mutant). Levofloxacin showed very little activity both in the in vitro pharmacodynamic model and in the animal model for the strain having a mutation in parC (levofloxacin and moxifloxacin minimum inhibitory concentrations, 2mg/L and 0.25mg/L, respectively). However, moxifloxacin still had a significant in vitro and in vivo activity against this strain.
PB Elsevier
SN 0924-8579
YR 2006
FD 2006-04
LK https://hdl.handle.net/20.500.14352/107096
UL https://hdl.handle.net/20.500.14352/107096
LA eng
NO Huelves L, Sevillano D, Martínez-Marín C, López-Casla MT, Gracia M, Alou L, del Carmen Ponte M, Prieto J, Soriano F; Spanish Pneumococcal Infection Study Network (G03/103). Correlation between in vitro and in vivo activity of levofloxacin and moxifloxacin against pneumococcal strains with different susceptibilities to fluoroquinolones. Int J Antimicrob Agents. 2006 Apr;27(4):294-9.
DS Docta Complutense
RD 22 abr 2025