RT Journal Article
T1 Endothelial vascular markers in coronary surgery
A1 Valencia Nuñez, Diana M.
A1 Kreutler, Willy
A1 Moya González, Javier
A1 Alados Arboledas, Pedro
A1 Muñoz Carvajal, Ignacio
A1 Carmona, Andrés
A1 Ramírez Chamond, Rafael
A1 Carracedo Añón, Julia María
AB Coronary heart disease is associated with high morbidity and mortality. Endothelial dysfunction in affected patients is linked to long-term atherosclerotic disease progression and cardiovascular event rates. The present paper reports on changes in the levels of endothelial progenitor cells (VEGFR2/CD133/CD34), essential for endothelial repair, and of endothelial microvesicles (CD31/annexin V) as indicators of endothelial lesion, in patients undergoing coronary bypass surgery with respect both to baseline levels and to counts in healthy subjects. In an observational descriptive study, 31 patients scheduled for coronary revascularization surgery were compared with those of 25 healthy controls. In a subsequent longitudinal study, patients undergoing surgery were monitored at 5 timepoints up until 48 h after surgery. Endothelial progenitor cell (VEGFR2/CD133/CD34) and endothelial microvesicle (CD31/annexin V) levels were quantified by flow cytometry. Baseline endothelial progenitor cell counts in coronary patients were significantly lower than those of healthy controls (p < 0.001); however, after surgery, levels rose steadily over all 5 timepoints to 48 h  with statistically significant differences (p < 0.001) between intra-operative and 48 h after surgery (T5). Endothelial microvesicle levels were significantly higher in coronary patients prior to surgery than in healthy controls (p < 0.001), and despite declining at 48 h remained significantly higher than those of controls (p < 0.001). Coronary surgery has had a positive impact on the endothelium in the patients, prompting a decrease in signs of endothelial dysfunction and a considerable improvement in the endothelial repair mechanisms involved in angiogenesis, playing an important role in the inflammatory response and the remodelling process of ischemic myocardium in postoperative period.
PB Springer
SN 0910-8327
YR 2017
FD 2017-06
LK https://hdl.handle.net/20.500.14352/131228
UL https://hdl.handle.net/20.500.14352/131228
LA eng
NO Valencia-Nuñez, D.M., Kreutler, W., Moya-Gonzalez, J. et al. Endothelial vascular markers in coronary surgery. Heart Vessels 32, 1390–1399 (2017). https://doi.org/10.1007/s00380-017-1006-3
NO Funding:This study was funded by Plan Nacional de I+D+i Proyectos de Investigación en Salud of Instituto de Salud Carlos III (ISCIII)-Subdirección General de Evaluación, Fondos de desarrollo regional (FEDER) (Grant Numbers PI12/01489, PI14/00806, PI15/01785), and Junta de Andalucía Grants (Grant Numbers P010-CTS-6337, P11-CTS-7352).
NO European Commission
NO Instituto de Salud Carlos III (España)
NO Junta de Andalucía
DS Docta Complutense
RD 26 feb 2026