RT Journal Article T1 Efficacy of 65% permethrin applied to dogs as a spot-on against Phlebotomus perniciosus A1 Molina Moreno, Ricardo A1 Espinosa Góngora, Carmen A1 Gálvez Esteban, Rosa María A1 Montoya Matute, Ana A1 Descalzo, Miguel Ángel A1 Jiménez Alonso, María Isabel A1 Dado, Diana A1 Miró Corrales, Guadalupe AB Leishmania infantum is a protozoan parasite causing leishmaniosis, a visceral disease transmitted by the bites of sand flies. As the main reservoir of the parasite, dogs are the principal targets of control measures against this disease, which affects both humans and dogs. Several studies have revealed the usefulness of topical insecticide treatment (collars, spot-ons and sprays) in reducing the incidence and prevalence of L. infantum. The present study was designed to test the efficacy of 65% permethrin applied to dogs as a spot-on against the sand fly vector Phlebotomus perniciosus. The duration of the desired effects was also estimated to help design an optimal treatment regimen. Twelve dogs assigned to treatment (n = 6) and control (n = 6) groups were exposed to sand flies once a week over a seven-week period. Repellent and insecticidal efficacies were estimated and compared amongst the groups. Our findings indicate satisfactory repellent, or anti-feeding, effects lasting 3 weeks and short-term insecticidal effects lasting 2 weeks after initial application. Accordingly, we recommend the use of this product every 2–3 weeks during the active phlebotomine sand fly period to protect dogs against the bites of P. perniciosus. PB Elsevier SN 0304-4017 YR 2012 FD 2012 LK https://hdl.handle.net/20.500.14352/110230 UL https://hdl.handle.net/20.500.14352/110230 LA eng NO Molina R, Espinosa-Góngora C, Gálvez R, Montoya A, Descalzo MA, Jiménez MI, Dado D, Miró G. (2012). Efficacy of 65% permethrin applied to dogs as a spot-on against Phlebotomus perniciosus. Veterinary Parasitology, 187(3-4):529-33. NO Supplementary data associated with this article can be found, in the online version, at doi:10.1016/j.vetpar.2012.01.024. DS Docta Complutense RD 8 abr 2025