RT Journal Article
T1 Bartonella Endocarditis in Spain: Case Reports of 21 Cases
A1 García Álvarez, Lara
A1 García García, María Concepción
A1 Muñoz García, Patricia Carmen
A1 Fariñas Álvarez, María del Carmen
A1 Cuadra, Manuel Gutiérrez
A1 Fernández Hidalgo, Nuria
A1 García Vázquez, Elisa
A1 Moral Escudero, Encarnación
A1 Alonso Socas, María del Mar
A1 García Rosado, Dácil
A1 Hidalgo Tenorio, Carmen
A1 Domínguez, Fernando
A1 Goikoetxea Agirre, Josune
A1 Gainzarain, Juan Carlos
A1 Rodríguez Esteban, María Ángeles
A1 Bosch Guerra, Xerach
A1 Oteo, José A.
AB Blood culture negative endocarditis (BCNE) is frequent in infective endocarditis (IE). One of the causes of BCNE is fastidious microorganisms, such as Bartonella spp. The aim of this study was to describe the epidemiologic, clinical characteristics, management and outcomes of patients with Bartonella IE from the “Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España (GAMES)”cohort. Here we presented 21 cases of Bartonella IE. This represents 0.3% of a total of 5590 cases and 2% of the BCNE from the GAMES cohort. 62% were due to Bartonella henselae and 38% to Bartonella quintana. Cardiac failure was the main presenting form (61.5% in B. hensalae, 87.5% in B. quintana IE) and the aortic valve was affected in 85% of the cases (76% in B. henselae, 100% in B. quintana IE). Typical signs such as fever were recorded in less than 40% of patients. Echocardiography showed vegetations in 92% and 100% of the patients with B. henselae and B. quintana, respectively. Culture was positive only in one patient and the remaining were diagnosed by serology and PCR. PCR was the most useful tool allowing for diagnosis in 16 patients (100% of the studied valves). Serology, at titers recommended by guidelines, only coincided with PCR in 52.4%. Antimicrobial therapy, in different combinations, was used in all cases. Surgery was performed in 76% of the patients. No in-hospital mortality was observed. One-year mortality was 9.4%. This article remarks the importance for investigating the presence of Bartonella infection as causative agent in all BCNE since the diagnosis needs specific microbiological tools and patients could benefit of a specific treatment.
PB MPDI
SN 2076-0817
YR 2022
FD 2022-05-10
LK https://hdl.handle.net/20.500.14352/72525
UL https://hdl.handle.net/20.500.14352/72525
LA eng
NO García Álvarez, L., García Gracía, M. C., Muñoz García, P. et al. «Bartonella Endocarditis in Spain: Case Reports of 21 Cases». Pathogens, vol. 11, n.o 5, mayo de 2022, p. 561. DOI.org (Crossref), https://doi.org/10.3390/pathogens11050561.
DS Docta Complutense
RD 11 abr 2025